Table 1 Haplotype analysis revealed a common risk haplotype for idiopathic epilepsy. A risk haplotype shared between the breeds was identified between 15085438 and 15113325 bp on CFA37. It consisted of alleles T-C-del-del-G-G at 15085438, 15106446, 15108593, 15108802, 15111724 and 15113325 bp in ADAM23
From: Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene
Breed | Risk haplo freq. cases | Risk haplo freq. controls | p-value | OR (95 % C.I.) | P-value (homozygosity) | OR (95 % C.I.) (homozygosity) | Cases/controls without risk haplotype |
|---|---|---|---|---|---|---|---|
Belgian Shepherd | 0.75 | 0.49 | 4.3e–11 | 3.2 (2.3–4.6) | 4.1e–10 | 4.6 (2.8–7.6) | 10 %/28 % |
Schipperke | 0.81 | 0.65 | 0.003 | 2.3 (1.3–4.0) | 0.0006 | 3.3 (1.7–6.7) | 6 %/9 % |
Finnish Spitz | 0.89 | 0.67 | 1.6e–05 | 4.1 (2.1–8.2) | 4.9e–05 | 4.9 (2.2–10.8) | 2 %/12 % |
Beagle (Finnish hunting) | 0.96 | 0.7 | 0.006 | 11.5 (1.4–93.1) | 0.009 | 12 (1.4–106.2) | 0 %/12 % |
Beagle (German) | 0.63 | 0.65 | 0.9 | 0.9 (0.3–2.6) | 0.9 | 1.1 (0.3–4.6) | 19 %/13 % |