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Fig. 5 | BMC Genomics

Fig. 5

From: Partial depletion of yolk during zebrafish embryogenesis changes the dynamics of methionine cycle and metabolic genes

Fig. 5

CpG density is reduced in genes that are deregulated. The empirical cumulative distribution (see methods) of the number of CpG sites in all genes (black) projected onto the number of CpG sites in DE genes. a Left panel: at 8 hpf, the Kolmogorov-Smirnov test reveals a significant reduction of CpG sites in promotor regions of DE genes that are up-regulated in YD (P-value in top left corner). Right panel: this depletion is most prominent around 5′ of the gene, including the proximal part of the cds. Five-hundred nt windows of the unspliced gene (top) and cds (bottom) are shown. b As in (a). At 32 hpf, a significant reduction of CpG sites in promotor regions and around the TSS is observed in DE genes that are down-regulated in YD. YD: up-regulated in YD; SP: down-regulated in YD; ALL: all available Ensembl-annotated genes

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BMC Genomics

ISSN: 1471-2164

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