Table 1 DMR-associated genes linked to cardiovascular disease
Hypermethylation and Hypomethylation in Atherosusceptible Endothelium in vivo | |
|---|---|
Hypermethylation | |
Gene Symbol | Gene name |
AGT | Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
ASIC1 | Acid-sensing (proton-gated) ion channel 1 |
BGLAP | Bone gamma-carboxyglutamate (gla) protein; polyamine-modulated factor 1 |
CA3 | Carbonic anhydrase III, muscle specific |
CCM2 | Cerebral cavernous malformation 2 |
COL28A1 | Collagen, type XXVIII, alpha 1 |
DICER1 | Dicer 1, ribonuclease type III |
EGLN3 | egl nine homolog 3 (C. elegans) |
ERN1 | Endoplasmic reticulum to nucleus signaling 1 |
HAND2 | Heart and neural crest derivatives expressed 2 |
HOXA4 | Homeobox A4 |
HOXA5# | Homeobox A5 [20] |
ISL1 | ISL LIM homeobox 1 |
ITGA5 | Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
LCP2 | Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76Â kDa) |
mir-10a | microRNA 10a |
MMP9 | Matrix metallopeptidase 9 (gelatinase B, 92Â kDa gelatinase, 92Â kDa type IV collagenase) |
PITX2 | Paired-like homeodomain 2 |
SGCB | Sarcoglycan, beta (43Â kDa dystrophin-associated glycoprotein) |
SLC25A4 | Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
SOD2 | Superoxide dismutase 2, mitochondrial |
SOX9 | SRY (sex determining region Y)-box 9 |
TBX20 | T-box 20 |
VSNL1 | Visinin-like 1 |
Hypomethylation | |
Gene Symbol | Gene Name |
ADRA2A | Adrenergic, alpha-2A-, receptor |
ALS | Superoxide dismutase 1, soluble |
APLN | Apelin |
BMP7 | Bone morphogenetic protein 7 |
CACNA1E | Calcium channel, voltage-dependent, R type, alpha 1E subunit |
CHRNA2 | Cholinergic receptor, nicotinic, alpha 2 (neuronal) |
EPHX2 | Epoxide hydrolase 2, cytoplasmic |
EPO | Erythropoietin |
FOXO1 | Forkhead box O1 |
GNAS | GNAS complex locus |
HOPX | HOP homeobox |
HOXA3 | Homeobox A3 |
HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B |
IGF1R | Insulin-like growth factor 1 receptor |
IL4 | Interleukin 4 |
IL8 | Interleukin 8 |
IMPDH1 | IMP (inosine monophosphate) dehydrogenase 1 |
ITGA2B | Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
KLF4 | Kruppel-like factor 4 (gut) |
LIF | Leukemia inhibitory factor (cholinergic differentiation factor) |
LIMK1 | LIM domain kinase 1 |
LIMS1 | LIM and senescent cell antigen-like domains 1 |
LTB4R | leukotriene B4 receptor |
mir-199a-1 | microRNA 199a1 |
mir-214 | microRNA 214 |
MMP11 | Matrix metallopeptidase 11 (stromelysin 3) |
NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 |
NGFR | nerve growth factor receptor (TNFR superfamily, member 16) |
PDZD2 | PDZ domain containing 2 |
PLEKHB1 | Pleckstrin homology domain containing, family B (evectins) member 1 |
PPARD | Peroxisome proliferator-activated receptor delta |
RETN | Resistin |
RORC | RAR-related orphan receptor C |
SERPINA5 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 |
THBS2 | Thrombospondin 2 |
TNS3 | Tensin 3 |
TTR | Transthyretin |