Table 2 Ten most significant gene sets enriched in PC1 correlating genes. Tables a and b are subsets of gene sets that were significantly (FDR q-value < 1 %) enriched in PC1 correlating genes by PC-GSEA (for full data, see Additional file 10: Table S7). (a) Gene sets in positively correlated genes, which were upregulated in SGs, and (b) gene sets in negatively correlated genes, which were upregulated in KCs and HaCaTs. SIZE is number of genes belonging the gene set. NES is normalized enrichment score

(a)

PEREZ_TP53_AND_TP63_TARGETS

198

2.967

0

SMID_BREAST_CANCER_NORMAL_LIKE_UP

449

2.908

0

BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN

31

2.774

0

KRAS.LUNG_UP.V1_DN

128

2.774

0

ABATES_COLORECTAL_ADENOMA_DN

248

2.760

0

WU_SILENCED_BY_METHYLATION_IN_BLADDER_CANCER

53

2.758

0

PEREZ_TP63_TARGETS

334

2.742

0

WINNEPENNINCKX_MELANOMA_METASTASIS_DN

46

2.735

0

KEGG_ASTHMA

23

2.689

0

KEGG_ALLOGRAFT_REJECTION

33

2.663

0

(b)

YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13

172

3.060

0

MOOTHA_VOXPHOS

86

3.038

0

WONG_EMBRYONIC_STEM_CELL_CORE

332

3.028

0

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTH ESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_ BY_UNCOUPLING_PROTEINS_

81

3.016

0

FOURNIER_ACINAR_DEVELOPMENT_LATE_2

276

3.005

0

KEGG_OXIDATIVE_PHOSPHORYLATION

111

2.954

0

PENG_LEUCINE_DEPRIVATION_DN

186

2.947

0

GSE22886_UNSTIM_VS_IL15_STIM_NKCELL_DN

199

2.947

0

WONG_MITOCHONDRIA_GENE_MODULE

216

2.943

0

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT

65

2.924

0