Fig. 4

Interaction network of gp120-deregulated miRs and predicted targets in HIV gp120 exposed MDDCs. Many different pathways (JAK-STAT signaling, MAPK signaling, PI3k-Akt signaling, NF-kB signaling, apoptosis, and cytokine-cytokine receptor interaction) have been joined into a unified network of interactions, representing genes potentially involved in DC response to gp120. Three different colored dots were placed next to genes to indicate the putative targeting by miR-155 (red dot), miR-181b (green dot) or miR-21 (blue dot). *Not listed as predicted target but experimentally validated [65]