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Table 4 Gene Ontology analysis for STAT3-deregulated miRNA (combined and individual predictions)

From: HIV-1 gp120 influences the expression of microRNAs in human monocyte-derived dendritic cells via STAT3 activation

Gene Ontology ID Gene Ontology Term No. of genes % p-value Corrected p-value (FDR)
Target genes for miR-155
GO:0006350 transcription 246 16.8 1.06E-11 1.93E-08
GO:0045449 regulation of transcription 288 19.7 6.23E-11 1.13E-07
GO:0051252 regulation of RNA metabolic process 201 13.8 1.30E-07 2.35E-04
GO:0006355 regulation of transcription, DNA-dependent 197 13.5 1.57E-07 2.85E-04
Target genes for miR-181b
GO:0045449 regulation of transcription 488 18.7 7.49E-13 1.40E-09
GO:0006350 transcription 406 15.6 2.00E-12 3.75E-09
GO:0051252 regulation of RNA metabolic process 345 13.2 1.05E-09 1.97E-06
GO:0006355 regulation of transcription, DNA-dependent 338 13.0 1.32E-09 2.47E-06
Combined target genes for miR-21, miR-155 and miR-181b
GO:0006350 transcription 647 15.3 1.13E-19 2.15E-16
GO:0045449 regulation of transcription 772 18.2 4.94E-19 9.40E-16
GO:0051252 regulation of RNA metabolic process 539 12.7 9.54E-13 1.82E-09
GO:0006355 regulation of transcription, DNA-dependent 527 12.4 1.92E-12 3.66E-09
GO:0016481 negative regulation of transcription 154 3.6 1.88E-07 3.57E-04
GO:0010629 negative regulation of gene expression 166 3.9 2.28E-07 4.34E-04
GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 163 3.8 3.00E-06 5.72E-3
GO:0051172 negative regulation of nitrogen compound metabolic process 164 3.9 4.54E-06 8.64E-3
GO:0031327 negative regulation of cellular biosynthetic process 175 4.1 5.03E-06 9.57E-3
GO:0010558 negative regulation of macromolecule biosynthetic process 171 4.0 5.71E-06 1.09E-2
GO:0009890 negative regulation of biosynthetic process 176 4.2 1.29E-05 2.45E-2
GO:0000122 negative regulation of transcription from RNA polymerase II promoter 92 2.2 1.81E-05 3.45E-2
GO:0007167 enzyme linked receptor protein signaling pathway 113 2.7 1.97E-05 3.75E-2
GO:0006357 regulation of transcription from RNA polymerase II promoter 215 5.1 2.18E-05 4.16E-2
  1. The table shows the Gene Onthology terms obtained after the bioinformatics analysis on the genes targeted by STAT3-regulated miRs, taken individually or in combination