| |
Stress exposuresa
|
|---|
| |
None
|
MSB
|
L-H2O2
|
H-H2O2
|
tBOOH
|
Diamide
|
NaCl
|
All
|
|---|
|
THS30.3 control strain
|
|
Up-regulation
| | | | | | | | |
|
Key genesb
|
-
|
11
|
2**
|
5
|
16
|
16
|
4
|
29
|
|
All genesc
|
-
|
65
|
17**
|
25**
|
65
|
71
|
34**
|
155
|
|
Clustersd
|
-
|
2
|
0
|
0
|
3
|
1
|
0
|
5
|
|
Down-regulation
| | | | | | | | |
|
Key genes
|
-
|
11
|
3
|
8
|
8
|
8
|
9
|
19
|
|
All genes
|
-
|
46
|
22
|
37
|
38***
|
52
|
39
|
112
|
|
Clusters
|
-
|
5
|
1
|
0
|
1
|
3
|
2
|
7
|
|
TNJ 92.4 ΔatfA strain
|
|
Up-regulation
| | | | | | | | |
|
Key genes
|
-
|
16
|
15*
|
16*
|
11
|
11
|
1
|
42
|
|
All genes
|
-
|
53
|
48*
|
68*
|
60
|
54
|
29
|
179
|
|
Clusters
|
-
|
2
|
3
|
2
|
2
|
0
|
0
|
7
|
|
Down-regulation
| | | | | | | | |
|
Key genes
|
-
|
5***
|
3***
|
5***
|
19*
|
20*
|
17***
|
31
|
|
All genes
|
-
|
16*,***
|
22***
|
26***
|
71*
|
82*
|
70*,***
|
139
|
|
Clusters
|
-
|
0
|
1
|
2
|
5
|
7***
|
5
|
9
|
|
TNJ 92.4 (ΔatfA) vs. THS30.3 (control)
|
|
Up-regulation
| | | | | | | | |
|
Key genes
|
11
| | | | | | | |
|
All genes
|
43
| | | | | | | |
|
Clusters
|
4
| | | | | | | |
|
Down-regulation
| | | | | | | | |
|
Key genes
|
5
| | | | | | | |
|
All genes
|
22***
| | | | | | | |
|
Clusters
|
0
| | | | | | | |
- *Significant difference between the THS30.3 control and TNJ 92.4 (ΔatfA) strain according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
- **Significant difference in comparison to MSB, tBOOH and diamide treatment as well (in the same row) according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
- ***Significant difference between the up- and down-regulated genes according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
-
aStressor concentrations are presented in footnotes to Table 2
-
bKey genes were defined as secondary metabolite cluster genes encoding transcription factors, non-ribosomal peptide synthases, polyketide synthases, terpene synthase or prenyltransferases according to Inglis et al. [114]
-
cOnly genes of clusters determined either manually or experimentally were involved in the analysis [114]
-
dClusters were regarded as up-regulated (or down-regulated) cluster if at least one of its key genes and more than half of its manually or experimentally determined genes were up-regulated (down-regulated)
