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Table 6 Stress dependent regulation of secondary metabolite genes and clusters

From: Core oxidative stress response in Aspergillus nidulans

  Stress exposuresa
  None MSB L-H2O2 H-H2O2 tBOOH Diamide NaCl All
THS30.3 control strain
Up-regulation         
Key genesb - 11 2** 5 16 16 4 29
All genesc - 65 17** 25** 65 71 34** 155
Clustersd - 2 0 0 3 1 0 5
Down-regulation         
Key genes - 11 3 8 8 8 9 19
All genes - 46 22 37 38*** 52 39 112
Clusters - 5 1 0 1 3 2 7
TNJ 92.4 ΔatfA strain
Up-regulation         
Key genes - 16 15* 16* 11 11 1 42
All genes - 53 48* 68* 60 54 29 179
Clusters - 2 3 2 2 0 0 7
Down-regulation         
Key genes - 5*** 3*** 5*** 19* 20* 17*** 31
All genes - 16*,*** 22*** 26*** 71* 82* 70*,*** 139
Clusters - 0 1 2 5 7*** 5 9
TNJ 92.4 (ΔatfA) vs. THS30.3 (control)
Up-regulation         
Key genes 11        
All genes 43        
Clusters 4        
Down-regulation         
Key genes 5        
All genes 22***        
Clusters 0        
  1. *Significant difference between the THS30.3 control and TNJ 92.4 (ΔatfA) strain according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
  2. **Significant difference in comparison to MSB, tBOOH and diamide treatment as well (in the same row) according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
  3. ***Significant difference between the up- and down-regulated genes according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
  4. aStressor concentrations are presented in footnotes to Table 2
  5. bKey genes were defined as secondary metabolite cluster genes encoding transcription factors, non-ribosomal peptide synthases, polyketide synthases, terpene synthase or prenyltransferases according to Inglis et al. [114]
  6. cOnly genes of clusters determined either manually or experimentally were involved in the analysis [114]
  7. dClusters were regarded as up-regulated (or down-regulated) cluster if at least one of its key genes and more than half of its manually or experimentally determined genes were up-regulated (down-regulated)