| Stress exposuresa
|
---|
 | None | MSB | L-H2O2
| H-H2O2
| tBOOH | Diamide | NaCl | All |
---|
THS30.3 control strain |
Up-regulation
| Â | Â | Â | Â | Â | Â | Â | Â |
Key genesb
| - | 11 | 2** | 5 | 16 | 16 | 4 | 29 |
All genesc
| - | 65 | 17** | 25** | 65 | 71 | 34** | 155 |
Clustersd
| - | 2 | 0 | 0 | 3 | 1 | 0 | 5 |
Down-regulation
| Â | Â | Â | Â | Â | Â | Â | Â |
Key genes | - | 11 | 3 | 8 | 8 | 8 | 9 | 19 |
All genes | - | 46 | 22 | 37 | 38***
| 52 | 39 | 112 |
Clusters | - | 5 | 1 | 0 | 1 | 3 | 2 | 7 |
TNJ 92.4 ΔatfA strain |
Up-regulation
| Â | Â | Â | Â | Â | Â | Â | Â |
Key genes | - | 16 | 15* | 16* | 11 | 11 | 1 | 42 |
All genes | - | 53 | 48* | 68* | 60 | 54 | 29 | 179 |
Clusters | - | 2 | 3 | 2 | 2 | 0 | 0 | 7 |
Down-regulation
| Â | Â | Â | Â | Â | Â | Â | Â |
Key genes | - | 5*** | 3*** | 5*** | 19* | 20* | 17*** | 31 |
All genes | - | 16*,*** | 22*** | 26*** | 71* | 82* | 70*,*** | 139 |
Clusters | - | 0 | 1 | 2 | 5 | 7*** | 5 | 9 |
TNJ 92.4 (ΔatfA) vs. THS30.3 (control) |
Up-regulation
| Â | Â | Â | Â | Â | Â | Â | Â |
Key genes | 11 | Â | Â | Â | Â | Â | Â | Â |
All genes | 43 | Â | Â | Â | Â | Â | Â | Â |
Clusters | 4 | Â | Â | Â | Â | Â | Â | Â |
Down-regulation
| Â | Â | Â | Â | Â | Â | Â | Â |
Key genes | 5 | Â | Â | Â | Â | Â | Â | Â |
All genes | 22*** | Â | Â | Â | Â | Â | Â | Â |
Clusters | 0 | Â | Â | Â | Â | Â | Â | Â |
- *Significant difference between the THS30.3 control and TNJ 92.4 (ΔatfA) strain according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
- **Significant difference in comparison to MSB, tBOOH and diamide treatment as well (in the same row) according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
- ***Significant difference between the up- and down-regulated genes according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
-
aStressor concentrations are presented in footnotes to Table 2
-
bKey genes were defined as secondary metabolite cluster genes encoding transcription factors, non-ribosomal peptide synthases, polyketide synthases, terpene synthase or prenyltransferases according to Inglis et al. [114]
-
cOnly genes of clusters determined either manually or experimentally were involved in the analysis [114]
-
dClusters were regarded as up-regulated (or down-regulated) cluster if at least one of its key genes and more than half of its manually or experimentally determined genes were up-regulated (down-regulated)