Fig. 9
From: Systematically dissecting the global mechanism of miRNA functions in mouse pluripotent stem cells
A system view of miRNAs primary mechanistic roles in maintaining pluripotency in pluripotent stem cells. MiRNAs directly repress both the DNA methylation system and the development, while indirectly regulate pluripotency genes. Reduced DNA methylation activates the miRNAs and pluripotent core factors for pluripotency. The activated circuit between miRNAs and DNA methylation, as well as the development inhibition, help stem cells to maintain the pluripotent state, see text for detail. The solid lines are directly derived from the present study and they represent direct interactions and the dash dark line represents indirect interactions, while dash green lines denote evidences from reference papers.