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Table 5 Significantly enriched human TFs for the downregulated genes in the EMT process. The enriched transcription factors (TFs) were inferred by comparing ChIP-Seq or ChIP-chip identified target genes (TGs) of each TF with the downregulated DEGs in the EMT process. The enriched TFs were sorted according to the enriched fold ratios

From: Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition

Human TFs

PMID

# total TGs

# DETGs

Fold ratio

Corrected p-value

Cell lines

TP63

17297297

34

14

3.9

1.1E-04

HaCaT

TRIM28

21343339

85

22

3

7.4E-04

HEK293

ESR2

21235772

392

98

2.9

<3.45E-14

MCF-7

CTNNB1

24651522

138

30

2.5

6.5E-04

LGR5+ INTESTINAL STEM CELL

SOX2

20726797

2060

433

2.4

<<3.45E-141.0E-16

SW620

IRF1

21803131

326

67

2.4

5.9E-09

MONOCYTES

TFAP2C

20629094

1125

229

2.4

<3.45E-14 < 3.45E-14 < 3.45E-14

MCF7

ESR1

21235772

213

43

2.3

4.1E-05

MCF-7

ZNF217

24962896

1400

271

2.2

<3.45E-14

MCF7

FOXM1

23109430

253

47

2.2

1.4E-04

U2OS

NR1H3

23393188

574

104

2.1

8.6E-11

ATHEROSCLEROTIC-FOAM

CDX2

20551321

383

69

2.1

1.2E-06

CACO-2

BACH1

22875853

1183

211

2.1

<3.45E-14

HELA-AND-SCP4

AHR

22903824

621

109

2

1.9E-10

MCF7

FOXO3

23340844

650

114

2

5.9E-11

DLD1

AR

21909140

258

45

2

1.5E-03

LNCAP PROSTATE CANCER CELL LINES

TP53

16413492

276

48

2

7.8E-04

HCT116

SMAD2

18955504

1643

285

2

<3.45E-14

HaCaT

SMAD3

18955504

1643

285

2

<3.45E-14

HaCaT

TP53

18474530

734

122

1.9

3.9E-10

U2OS

RELA

24523406

1147

187

1.9

<3.45E-14

A549

TP63

23658742

3355

541

1.9

<3.45E-14

EP156T

ARNT

22903824

912

147

1.9

2.2E-11

MCF7

SMAD4

19686287

348

56

1.9

1.4E-03

HaCaT

TCF4

18268006

392

63

1.9

3.9E-04

LS174T

CLOCK

20551151

398

62

1.8

1.3E-03

293 T

PAX3-FKHR

20663909

975

144

1.7

3.1E-08

RHABDOMYOSARCOMA

TP63

22573176

3867

570

1.7

<3.45E-14

HFKS

GATA1

19941826

700

103

1.7

1.9E-05

K562

SMAD3

21741376

1074

158

1.7

4.8E-09

HESC

CTNNB1

20460455

900

130

1.7

1.1E-06

HCT116

FOXA2

19822575

2791

402

1.7

<3.45E-14

HepG2

SMAD4

21741376

2032

290

1.7

<3.45E-14

HESC

ELF5

23300383

920

130

1.6

4.2E-06

T47D

GATA2

19941826

1727

241

1.6

5.2E-12

K562

TRIM28

17542650

680

94

1.6

1.2E-03

NTERA2

GATA2

21666600

634

87

1.6

3.6E-03

HMVEC

AR

19668381

2958

398

1.6

<3.45E-14

PC3

HNF4A

19761587

816

108

1.5

1.7E-03

HUMAN INTESTINAL CELL LINE CACO-2

AR

22383394

1690

221

1.5

4.3E-08

PROSTATE_CANCER

  1. PMID pubmed article number; # total TGs number of ChIP-Seq or ChIP-chip identified target genes (TGs) of each TF; #DETGs number of differentially expressed genes
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BMC Genomics

ISSN: 1471-2164

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