InDel Set | NGS InDels | TPa
| FPb
| TNc
| FNd
| Sensitivity | Specificity | FP rate (1-specificity) | FN rate (1-sensitivity) | VRe
|
---|
Dindel | 17 | 15 | 2 | 9,739 | 4 | 0.7895 | 0.9998 | 0.0002 | 0.2105 | 0.8824 |
SAMtools | 17 | 16 | 1 | 9,740 | 3 | 0.8421 | 0.9999 | 0.0001 | 0.1579 | 0.9411 |
Consensus filtered6
| 15 | 14 | 1 | 9,740 | 5 | 0.7368 | 0.9999 | 0.0001 | 0.2631 | 0.9333 |
-
aTP = True Positive and this refers to the number of InDels detected by both Sanger and NGS methods. bFP = False Positive and this refers to the number of InDels detected only by NGS. cTN = True Negatives and refers to the number of bases which were sequenced but not called as InDels by Sanger or NGS. dFN = False Negative and refers to the number of InDels detected only by Sanger. eVR = Validation Rate was calculated as (TP/number of NGS InDels). fConsensus filtered set included the common InDels detected by both SAMtools and Dindel and retained after filtration