GeneBank IDa | Fold changeb | Tentative annotationc | Adj. P valued | ||
---|---|---|---|---|---|
Up-regulated in LS and HS families | LS | HS | Â | LS | HS |
Immune response | Â | Â | Â | Â | Â |
CB511680 | 1.468 | 1.642 | Lysozyme C II | 0.000 | 0.000 |
CA050178 | 0.171 | 0.497 | MHC class I (hla-UBA) | 0.022 | 0.008 |
CA063704 | 0.114 | 0.171 | CD97 antigen | 0.045 | 0.030 |
CB508464 | 0.329 | 0.311 | Canopy 4 (cnpy4) | 0.028 | 0.032 |
CA044420 | 0.408 | 0.293 | Aminopeptidase N | 0.024 | 0.044 |
CB493358 | 0.288 | 0.373 | Microsomal glutathione S-transferase 2 | 0.048 | 0.011 |
Energetic metabolism | Â | Â | Â | Â | Â |
CB500248 | 0.266 | 0.378 | ATP synthase subunit e, mitochondrial | 0.023 | 0.007 |
CA768741 | 0.273 | 0.301 | ATP synthase subunit epsilon, mitochondrial | 0.008 | 0.013 |
CA045510 | 0.252 | 0.252 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | 0.009 | 0.013 |
CK991263 | 0.169 | 0.219 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8 | 0.039 | 0.007 |
CB493482 | 0.251 | 0.276 | Glucagon-1 | 0.014 | 0.005 |
CB492183 | 0.289 | 0.243 | Succinyl-CoA ligase beta-chain | 0.007 | 0.040 |
CB497724 | 0.225 | 0.280 | Mitochondrial import receptor subunit TOM7 | 0.041 | 0.046 |
Organization and regulation of actin cytoskeleton | Â | Â | Â | Â | Â |
CA770217 | 0.160 | 0.345 | Actin, cytoplasmic 1 | 0.019 | 0.005 |
CB508611 | 0.264 | 0.293 | Thymosin beta-4 | 0.015 | 0.018 |
EG804880 | 0.231 | 0.294 | Tropomyosin alpha-3 chain | 0.037 | 0.012 |
EG783905 | 0.605 | 0.381 | Myosin light chain 3 | 0.026 | 0.009 |
BU965651 | 0.326 | 0.337 | Myosin light chain 4 | 0.010 | 0.012 |
DW564371 | 0.174 | 0.193 | Ras GTPase-activating protein nGAP (ngap) | 0.044 | 0.032 |
CB508887 | 0.248 | 0.306 | Ral guanine nucleotide dissociation stimulator | 0.021 | 0.021 |
Cell metabolism and regulation | Â | Â | Â | Â | Â |
CB507177 | 0.237 | 0.356 | Cell division protein kinase 10 | 0.018 | 0.015 |
DW577024 | 0.198 | 0.304 | Anaphase-promoting complex subunit 13 | 0.048 | 0.009 |
CB500559 | 0.227 | 0.251 | Casein kinase II subunit alpha | 0.009 | 0.017 |
CB492123 | 0.276 | 0.196 | Trafficking protein particle complex subunit 5 | 0.025 | 0.040 |
CA042337 | 0.156 | 0.174 | Charged multivesicular body protein 3 | 0.034 | 0.041 |
CB486725 | 0.202 | 0.326 | Vacuolar ATP synthase subunit S1 | 0.029 | 0.009 |
CB490914 | 0.252 | 0.309 | Fumarylacetoacetase | 0.040 | 0.008 |
CB492396 | 0.199 | 0.277 | Cytosolic 5-nucleotidase III | 0.046 | 0.024 |
Stress response | Â | Â | Â | Â | Â |
CA045475 | 0.313 | 0.407 | Pro-opiomelanocortin | 0.026 | 0.004 |
CA047150 | 0.334 | 0.292 | Pro-opiomelanocortin A2s | 0.013 | 0.009 |
CA054693 | 0.157 | 0.246 | Alcohol dehydrogenase class-3 | 0.048 | 0.020 |
EG824838 | 0.184 | 0.297 | Microsomal glutathione S-transferase 3 | 0.033 | 0.022 |
CB498572 | 0.245 | 0.246 | Gamma-glutamyl hydrolase | 0.017 | 0.027 |
Gene expression | Â | Â | Â | Â | Â |
EG812701 | 0.579 | 0.809 | Histone deacetylase complex subunit SAP30L | 0.000 | 0.020 |
CA045554 | 0.310 | 0.332 | Neurogenic differentiation factor 1 | 0.026 | 0.012 |
CB493607 | 0.313 | 0.219 | Small nuclear ribonucleoprotein-associated protein B | 0.002 | 0.013 |
CA058810 | 0.231 | 0.243 | Eukaryotic translation initiation factor 1A | 0.014 | 0.011 |
CA060458 | 0.297 | 0.449 | Eukaryotic translation initiation factor 5A-1 | 0.023 | 0.012 |
Down-regulated in LS and HS families | LS | HS | Â | LS | HS |
Synthesis of proteins | Â | Â | Â | Â | Â |
CA045933 | −0.703 | −0.707 | 40S ribosomal protein S27 | 0.000 | 0.002 |
CA051651 | −0.562 | −0.403 | 40S ribosomal protein S5 | 0.008 | 0.026 |
CB497637 | −0.610 | −0.409 | 40S ribosomal protein S19 | 0.017 | 0.025 |
CA037570 | −0.590 | −0.840 | 60S ribosomal protein L27 | 0.002 | 0.000 |
CA768633 | −0.585 | −0.318 | 60S ribosomal protein L38 | 0.005 | 0.031 |
CB501170 | −0.629 | −0.517 | 60S ribosomal protein L36 | 0.002 | 0.001 |
Glycolysis, Oxidative Phosphorylation and mitochondrial transport | Â | Â | Â | Â | Â |
CA768062 | −0.318 | −0.654 | Glyceraldehyde-3-phosphate dehydrogenase | 0.005 | 0.017 |
CA052837 | −0.424 | −0.497 | Phosphoglycerate mutase 1 | 0.006 | 0.025 |
CN442520 | −1.051 | −1.070 | Cytochrome oxidase subunit 2 | 0.001 | 0.000 |
CB493612 | −0.461 | −0.909 | Cytochrome oxidase subunit 3 | 0.014 | 0.001 |
CN442526 | −0.311 | −0.420 | Cytochrome b | 0.029 | 0.009 |
CA063030 | −0.708 | −0.311 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | 0.038 | 0.048 |
CN442551 | −0.826 | −1.058 | NADH-ubiquinone oxidoreductase chain 1 | 0.001 | 0.008 |
CN442556 | −0.416 | −0.476 | NADH-ubiquinone oxidoreductase chain 2 | 0.000 | 0.043 |
BU965678 | −0.926 | −1.207 | NADH-ubiquinone oxidoreductase chain 3 | 0.000 | 0.008 |
CN442494 | −0.320 | −0.528 | NADH-ubiquinone oxidoreductase chain 4 | 0.043 | 0.019 |
CA042906 | −0.454 | −0.746 | ADP/ATP translocase 2 | 0.027 | 0.014 |
CA058445 | −0.187 | −0.313 | ADP/ATP translocase 2 | 0.034 | 0.009 |
CB502545 | −0.399 | −0.595 | Mitochondrial import inner membrane translocase subunit Tim23 | 0.043 | 0.000 |
CB498852 | −0.402 | −0.828 | Heat shock cognate 70 kDa protein | 0.031 | 0.000 |
Plasma transport of oxygen and selenium | Â | Â | Â | Â | Â |
CB492263 | −1.300 | −1.249 | Hemoglobin subunit alpha-4 | 0.013 | 0.009 |
BU965636 | −1.140 | −1.657 | Hemoglobin subunit beta | 0.044 | 0.003 |
CA049300 | −1.540 | −1.691 | Hemoglobin subunit beta-1 | 0.016 | 0.010 |
CB498665 | −1.140 | −1.164 | Hemoglobin subunit beta-4 | 0.035 | 0.042 |
CA044104 | −1.227 | −1.947 | Selenoprotein Pa | 0.000 | 0.000 |
CB510462 | −0.463 | −0.867 | Selenoprotein Pb | 0.015 | 0.000 |
Extracellular matrix organization and collagen biosynthesis | Â | Â | Â | Â | Â |
CA047568 | −0.216 | −0.223 | Collagen alpha-1(I) a chain | 0.024 | 0.046 |
CB488336 | −0.427 | −0.272 | Collagen alpha-1(I) a chain | 0.010 | 0.026 |
CA061635 | −0.568 | −0.239 | Collagen alpha-1(I) b chain | 0.001 | 0.046 |
CB493159 | −0.296 | −0.309 | Collagen alpha-2(I) chain | 0.005 | 0.021 |
CB492428 | −0.246 | −0.478 | Secreted protein acidic and rich in cysteine (SPARC) | 0.042 | 0.030 |
Homeostasis of metals (iron and copper) | Â | Â | Â | Â | Â |
CB509708 | −0.353 | −0.443 | Ferritin, heavy subunit | 0.002 | 0.005 |
CB510731 | −0.376 | −0.634 | Ferritin, middle subunit | 0.001 | 0.006 |
CA039497 | −0.337 | −0.736 | Hemopexin | 0.005 | 0.041 |
CB508872 | −0.767 | −0.712 | Metallothionein A | 0.009 | 0.029 |
CB507722 | −0.245 | −0.328 | Metallothionein B | 0.048 | 0.009 |