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Table 2 Positively selected genes with functions, identified in Arctic and red fox using the branch site test

From: Genetic signatures of adaptation revealed from transcriptome sequencing of Arctic and red foxes

Dog Ensemble transcript ID Gene Name Uniprot function Function (Additional details)
Arctic fox
ENSCAFT00000048935 GLTPD1 Glycolipid transfer protein domain containing 1 Glycolipid binding, Phospholipid binding. Lipid deposition in chicken [23].
ENSCAFT00000008666 AKT2 V-akt murine thymoma viral oncogene homolog 2 ATP binding. Regulation of fatty acid beta-oxidation and insulin signalling [25, 79].
Kinase activity.
ENSCAFT00000001161 N.A. N.A. Transmembrane transport. N.A.
ENSCAFT00000021080 RNASEH2C Ribonuclease H2, subunit C RNA catabolic process. Involved in Aicardi-Goutieres syndrome [80].
Red fox
ENSCAFT00000027282 MAGEE2 Melanoma antigen family E, 2 N.A. Member of the melanoma antigen family, unknown function [81].
ENSCAFT00000010371 APBB1 Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) Beta-amyloid binding. Interacts with the Alzheimer’s disease amyloid precursor protein (APP) [82, 83].
Chromatin binding.
ENSCAFT00000006986 CCDC61 Coiled-coil domain containing 61 N.A. N.A.
ENSCAFT00000012394 LIX1 Limb Expression 1 N.A Expressed during chicken and mouse limb development [84, 85].
ENSCAFT00000016648 SLC6A19 Solute carrier family 6, member 19 Neurotransmitter: sodium symporter activity. Involved in Hartnup disorder [86].
ENSCAFT00000032520 TK2 Thymidine kinase 2 ATP binding. Thymidine kinase activity. Required for mitochondrial DNA synthesis. Associated with a myopathic form of mitochondrial DNA depletion syndrome [87].
ENSCAFT00000013454 EDIL3 EGF-like repeats and discoidin I-like domains 3 Calcium ion binding. Integrin binding. Angiogenesis [88, 89] Involved in innate immunity [90].
ENSCAFT00000031005 DFFB DNA fragmentation factor, 40 kDa, beta polypeptide DNA binding. Caspase-activated DNAse. Involved in apoptosis [91, 92].
Desoxyribonuclease activity.
  1. Gene ontology functions were searched in the Uniprot ontology annotation (Uniprot-GOA)