Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids

Rangel-Zúñiga, Oriol Alberto; Camargo, Antonio; Marin, Carmen; Peña-Orihuela, Patricia; Pérez-Martínez, Pablo; Delgado-Lista, Javier; González-Guardia, Lorena; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Malagón, María M.; Pérez-Jiménez, Francisco; Roche, Helen M.; López-Miranda, José

doi:10.1186/s12864-015-1725-8

BMC Genomics

Table 3 Long-term effect of quantity and quality of dietary fat on proteome of cytoplasmic fraction of PBMC

From: Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids

*Proteomic changes Induced after 12 weeks of the intake of HSFA diet consumption*
Protein	Symbol	FC	p-Value
- Target of Myb protein 1	TOM1	2.06	0.027
- DNA-directed RNA polymerase III subunit	POLR3E	3.08	0.012
- Chain A, X-Ray Crystal Structure Of Zinc-Bound F95mW97V CARBONIC Anhydrase (Caii) Variant		UR	0.017
- Coiled-coil domain-containing protein 88B. Isoform 3	CCDC88B	DR	0.026
*Proteomic changes Induced after 12 weeks of the intake of HMUFA diet consumption*
Protein	Symbol	FC	p-Value
- Chloride intracellular channel 1 protein	CLIC1	0.63	0.032
- Protein disulfide isomerase-related protein 5	PDIA5	0.47	0.008
- Capping protein (actin filament) muscle Z-line, beta	CAPZ	0.32	0.024
- hCG1808619		DR	0.024
- Nuclear receptor-interacting protein 3	NRIP3	DR	0.023
- Zinc finger protein 791	ZFP791	1.89	0.038
*Proteomic changes Induced after 12 weeks of the intake of LFHCC diet consumption*
Protein	Symbol	FC	p-Value
- hCG2041202		0.62	0.001
- NF-kappa-B-activating kinase	TBK1	0.62	0.019
- Growth factor receptor-bound protein 2 isoform 1	GRB2	0.35	0.026
- Sry-related HMG box gene		0.16	0.007
- PSMA4 protein	PSMA4	1.81	0.071
- Voltage-dependent anion channel 2, isoform CRA_a	VDAC2	0.70	0.046
*Proteomic changes Induced after 12 weeks of the intake of LFHCC + n3 diet consumption*
Protein	Symbol	FC	p-Value
- Vacuolar protein sorting-associated protein 28 homol	VPS28	1.85	0.040
- BiP Protein	BiP	1.77	0.029
- Chloride intracellular channel 1 protein	CLIC1	0.40	0.013
- Beta actin	ACTB	DR	<0.05
- POTE-2 alpha actin	POTE-2	0.38	0.014
- Capping protein (actin filament) muscle Z-line, beta	CAPZ	DR	<0.05
- HSP70-2	HSP70-2	0.35	0.049
- Microtubule-actin cross-linking factor 1	MACF1	DR	<0.05
- S4-SRCRB		4.05	0.009
- Gelsolin	GSN	1.67	0.023

Proteins differentially expressed in the post-intervention compared to the baseline from an average of over 350 protein spots detected in the cytoplasmic fraction. FC: Fold change. T-test p-value. UR, up-regulated proteins, not detected at baseline but detected at post-intervention. DR, down- regulated, proteins detected at baseline but not detected at post-intervention

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ISSN: 1471-2164

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