Table 2 Leads to activation of inflammatory genes by identified TFs in response to TLR3 stimulation
From: Transcriptome sequencing of microglial cells stimulated with TLR3 and TLR4 ligands
STAT1 predicted to be activated (45 genes)p = 4.76 e-43) | IRF7 predicted to be activated (45 genes) (p = 1.33 e-43) | NFKBIA predicted to be activated (35 genes) (p = 5.31 e-30) | IRF1 predicted to be activated (24 genes) (p = 7.19 e-22) | JUNB predicted to be activated (7 genes) (p = 1.24 e-07) |
|---|---|---|---|---|
USP18, TRAFD1, TNF, TAP1, STAT2, SP110, SOCS3, SLFN5, SLFN2, SLFN13, SLFN12L, RSAD2, PTGS2, OASL, NEURL3, MX1/MX2, JAK2, ISG15, IRGM1, IRG1, IRF9, IRF7, IRF1, IL15, IGTP, IFIT2, IFIT1B, IFI35, IFI16, ICAM1, HERC6, EIF2AK2, CXCL10, CMPK2, CDKN1A, CD40, CD274, CD14, CCRL2, CCL2, CASP4, C3, APOBEC3B, CASP2, APOC2 | USP18, UBA7, TRIM5, TRIM30A, TRIM21, TREX1, TAP1, STAT2, STAT1, SAMD9L, RTP4, RSAD2, PLSCR1, PHF11, PELI1, PARP14, PARP12, OASL2, OASL, OAS3, OAS2, OAS1, MX1/MX2, JAK2, ISG15, IRGM1, IRGM, IRF9, IRF1, IL15, IGTP, IFIT2, IFIT1B, IFIH1, IFI35, IFI16, HELZ2, DHX58, DAXX, CXCL10, CMPK2, CD40, CCRL2, CASP4, ADAR | TNFAIP3, TNFAIP2, SOCS3, SLFN2, SAA3, RCAN1, RASA3, PTGS2, PLAU, NFKBIE, NFKB2, JUNB, JUN, ISG15, IRG1, IRF1, IL1RN, IL1A, IL15, IFIT1B, IFI16, ICAM1, HMOX1, HLA-A, GCH1, CLU, CEBPD, CCL9, CCL7, CCL3L3, CCL2, CASP4, AMPD3, MXD4, CXCR4 | TRIM21, TNF, TLR3, TAP1, STAT2, STAT1, RSAD2, PTGS2, PML, OAS1, JAK2, ISG15, IRF9, IRF7, IL1B, IL18, IL15, IFIT2, IFIH1, IFI35, EIF2AK2, CXCL10, CDKN1A, CD40, CASP2 | TNFRSF8, SERPINE1, PLAUR, PLAU, HMOX1, BCL3, ATF3 |