Fig. 5

Predicted effects of SNPs in miR-342 on pre-miR-342 structure. Top: sequence spanning 109,896,830-109,896,928 bp on Chr 12 with miR-342-5p and miR-342-3p sequences shown in blue and green, respectively. SNPs present in the musculus-derived haplotype are highlighted in red and by asterisks. Bottom: the sequence of miR-342 from C57BL/6J reference strain was used to generate a structure of pre-miR-342, shown on the left. The predicted effect of two SNPs (rs242689107 and rs264778660), present in the musculus-derived haplotype, is shown in the center. Note the change in the terminal loop as a function of SNPs. The predicted structure of pre-miR-342 with the addition of the indel (rs261236356) is shown at right