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Table 1 Description of the 17 hubs in the three functional interaction networks

From: Network analysis of temporal functionalities of the gut induced by perturbations in new-born piglets

  Gene symbol Function Summary
OnlyTr1 hubs GRB2 (17) Important link between growth factor receptors on the cell surface and Ras signalling Cell cycle/ Proliferation
STAT3 (15) In response to cytokines and growth factors, STAT family members are phosphorylated and translocate to the nucleus to function as transcription factors Immune
CDC42 (12) A GTP-ase involved in signalling for several processes, cell migration, morphology, endocytosis, cell cycle progression and cell proliferation Cell cycle/ Proliferation
CAV1 (11) Encodes a scaffolding protein that is an essential part of caveolar membranes Immune
FOS (11) The FOS family encodes for leucine zipper proteins. Regulates cell proliferation, differentiation, transformation and apoptotic cell death Cell cycle/ proliferation
Tr1&Tr2 hubs MYC (31) Transcription factor that activates growth related genes Cell cycle/ Proliferation
MAPK14 (24) Important for the cascades of cellular responses evoked by extracellular stimuli leading to direct activation of transcription factors  
RELA (24) Forms a complex with NFKB transcription factor and regulates the NFKB pathway Immune
UBE2D2 (24) Ubiquitin conjugating enzyme that catalyses covalent attachment of activated ubiquitin to other ubiquitin ligases Ubiquitination
ITCH (23) Ubiquitin-protein ligase which accepts ubiquitin from an ubiquitin-conjugating enzyme and then directly transfers the ubiquitin to targeted substrates Ubiquitination
IKBKG (22) Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NFKB and ultimately the degradation of the inhibitor Immune
SP1 (22) Transcription factor (activator or repressor) that regulates many cellular processes Cell cycle/ Proliferation
RHOA (20) Regulates signalling from plasma membrane receptors to the assembly of focal adhesions and actin stress fibers Cell cycle/ Proliferation
RPS3 (20) Component of the 40S ribosomal subunit, where translation is initiated  
FBXW7 (19) Part of the ubiquitin ligase complex (SCF) which recognizes and binds to phosphorylated targets Ubiquitination
OnlyTr2 hubs UBA52 (20) One of the four genes that code for ubiquitin, and ribosomal components which are part of the ribosome 60S subunit Ubiquitination
STAT1 (12) In response to cytokines and growth factors, STAT family members are phosphorylated and translocate to the nucleus to function as transcription factors Immune
  1. The number of connections of each gene in their respective network is given in brackets along with the gene symbol. The information about the genes is adapted from www.genecards.org. The hubs can be clustered into three broad groups, given in the last column, based on their functions. All these genes have significantly different time profiles in the treatment compared to the control