Table 1 Description of the 17 hubs in the three functional interaction networks
From: Network analysis of temporal functionalities of the gut induced by perturbations in new-born piglets
| Â | Gene symbol | Function | Summary |
|---|---|---|---|
OnlyTr1 hubs | GRB2 (17) | Important link between growth factor receptors on the cell surface and Ras signalling | Cell cycle/ Proliferation |
STAT3 (15) | In response to cytokines and growth factors, STAT family members are phosphorylated and translocate to the nucleus to function as transcription factors | Immune | |
CDC42 (12) | A GTP-ase involved in signalling for several processes, cell migration, morphology, endocytosis, cell cycle progression and cell proliferation | Cell cycle/ Proliferation | |
CAV1 (11) | Encodes a scaffolding protein that is an essential part of caveolar membranes | Immune | |
FOS (11) | The FOS family encodes for leucine zipper proteins. Regulates cell proliferation, differentiation, transformation and apoptotic cell death | Cell cycle/ proliferation | |
Tr1&Tr2 hubs | MYC (31) | Transcription factor that activates growth related genes | Cell cycle/ Proliferation |
MAPK14 (24) | Important for the cascades of cellular responses evoked by extracellular stimuli leading to direct activation of transcription factors | Â | |
RELA (24) | Forms a complex with NFKB transcription factor and regulates the NFKB pathway | Immune | |
UBE2D2 (24) | Ubiquitin conjugating enzyme that catalyses covalent attachment of activated ubiquitin to other ubiquitin ligases | Ubiquitination | |
ITCH (23) | Ubiquitin-protein ligase which accepts ubiquitin from an ubiquitin-conjugating enzyme and then directly transfers the ubiquitin to targeted substrates | Ubiquitination | |
IKBKG (22) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NFKB and ultimately the degradation of the inhibitor | Immune | |
SP1 (22) | Transcription factor (activator or repressor) that regulates many cellular processes | Cell cycle/ Proliferation | |
RHOA (20) | Regulates signalling from plasma membrane receptors to the assembly of focal adhesions and actin stress fibers | Cell cycle/ Proliferation | |
RPS3 (20) | Component of the 40S ribosomal subunit, where translation is initiated | Â | |
FBXW7 (19) | Part of the ubiquitin ligase complex (SCF) which recognizes and binds to phosphorylated targets | Ubiquitination | |
OnlyTr2 hubs | UBA52 (20) | One of the four genes that code for ubiquitin, and ribosomal components which are part of the ribosome 60S subunit | Ubiquitination |
STAT1 (12) | In response to cytokines and growth factors, STAT family members are phosphorylated and translocate to the nucleus to function as transcription factors | Immune |