Fig. 3
Quantitative proteomic comparison of FFPE derived ccRCC tumor tissue with FFPE derived, adjacent non-malignant tissue. Stable isotope labeling was achieved by reductive dimethylation with either light (12COH2) or heavy (13COD2) formaldehyde. a Box-and-whisker plots denoting the 25–75 percentile and the 5 – 95 percentiles, respectively, of the four replicates (b) Correlation of APEX scores [26, 27], showing the Pearson correlation. Protein and peptide identification numbers are 1518 proteins/6619 unique peptides for replicate 1; 2490 proteins/13501 unique peptides for replicate 2; 1590 proteins/12811 peptides for replicate 3; 1352 proteins/9207 peptides for replicate 4