Combined serial analysis of gene expression and transcription factor binding site prediction identifies novel-candidate-target genes of Nr2e1 in neocortex development

Table 1 Gene ontology (GO) term analysis revealed enrichment in relevant biological processes

GO identifiers and terms	No. of differentially expressed genes^a	P value after Bonferroni^b
GO:0006396 ~ RNA processing	55	4.39E-10
GO:0016070 ~ RNA metabolic process	68	7.54E-09
GO:0044267 ~ cellular protein metabolic process	132	2.96E-04
GO:0007067 ~ mitosis	26	3.12E-04
GO:0000280 ~ nuclear division	26	3.12E-04
GO:0015031 ~ protein transport	56	3.58E-04
GO:0045184 ~ establishment of protein localization	56	4.56E-04
GO:0000087 ~ M phase of mitotic cell cycle	26	4.66E-04
GO:0046907 ~ intracellular transport	42	6.08E-04
GO:0030163 ~ protein catabolic process	49	1.13E-03
GO:0044265 ~ cellular macromolecule catabolic process	52	1.27E-03
GO:0000279 ~ M phase	31	2.35E-03
GO:0051246 ~ regulation of protein metabolic process	35	3.82E-03
GO:0007399 ~ nervous system development^c	64	5.13E-03
GO:0022403 ~ cell cycle phase	33	6.36E-03
GO:0019538 ~ protein metabolic process	151	6.91E-03
GO:0006886 ~ intracellular protein transport	28	3.18E-02
GO:0034613 ~ cellular protein localization	29	4.95E-02

^a352 total non-overlapping differentially expressed genes
^b http://david.abcc.ncifcrf.gov/ease/Help/Technical%20details/Overrepresentation%20analysis.htm
^cterm used in subsequent analyses

ISSN: 1471-2164