A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance

Table 1 Positively selected sites in IR-IFITM genes detected using MEME method implemented in DATAMONKEY

Gene	Codon (AA)	Region	α	Pr[β = β⁻]	β⁺	Pr[β = β⁺]	p-value	Posterior Probability w+ > 1
IFITM1	30 V	N-term	0.00	9.38E-01	71.79	0.60	0.002	ANAPL**
	100 L	IM2	0.00	8.35E-01	6.49	0.17	0.015	PHALE**
	102 L	IM2	0.36	7.62E-01	9.23	0.24	0.050	EGRGA, LEPDI, CARCR*
	106 F	IM2	0.00	1.00E-09	1.30	1.00	0.035	ALL**
	112A	IM2	0.00	1.00E-09	1.43	1.00	0.020	ALL**
	117G	IM2	0.00	9.00E-01	173.17	0.10	0.032	CALAN**
	118 T	IM2	0.00	3.73E-01	2.06	0.63	0.024	MESUN, PHALE, CALUM, CUCCU
	135P	C-term	0.00	3.63E-01	5.84	0.64	0.007	CHAPE, PELCR, EGRGA, HALAL, COLST**
IFITM3	98A	CLIP	0.63	9.28E-01	94.87	0.07	0.048	APTFO*
	119 L	IM2	0.00	3.82E-01	4.31	0.62	0.050	ANAPL, MESUN, NIPNI, PYGAD**, GALGA
	136I	IM2	0.00	8.35E-01	14.92	0.16	0.004	CUCCA**

This summary table reports the distribution of synonymous (α) and non-synonymous (β) substitution rates over sites inferred by the MEME model, where the proportion of branches with β > α is significantly greater than 0; p-value is derived using a mixture of χ2 distributions, **p-value < 0.01; *p-value < 0.05

ISSN: 1471-2164