Fig. 2

TRD genes. In a, the IMGT Protein display of the sheep TRDV genes. Only functional genes, ORF and in-frame pseudogenes are shown. The description of the strands and loops and of the FR-IMGT and CDR-IMGT is according to the IMGT unique numbering for V-REGION [27]. The CDR-IMGT AA lengths are indicated in square brackets. nd: not defined (indicates that the AA sequence of the TRDV1S6 gene is incomplete and its functionality cannot be defined). In b and c, nucleotide and deduced AA sequences of the sheep TRDD and TRDJ genes. The consensus sequences of the heptamer and nonamer [41] are provided at the top of the figure and underlined. The numbering adopted for the gene classification is reported on the left of each gene. In b, the AA sequences of the TRDD genes in the three coding frames are reported. In c, the donor splice site for each TRDJ is shown. The canonical FGXG motifs are underlined. The unusual TRDJ1-4 gene motif is in italics. In d, IMGT Protein display of the TRDC gene. Description of the strands and loops is according to the IMGT unique numbering for C-DOMAIN [42]