Fig. 3

Transcriptomic Responses of Genes of Interest. Two subsets of genes were selected for visualization and comparison with additional datasets: 10 “AHR-core” genes and 21 genes determined to be significantly altered (|log₂ fold-change| > 1.5 and p _adj < 0.01) following all four doses of TCDD in either male or female mice. The magnitude (dot size), direction (dot colour: orange and blue representing increased and decreased abundance respectively) and significance (background shading representing FDR-adjusted p-values) of changes relative to control animals are shown. Results for the “AHR-core” genes (top) and genes of interest (bottom) are shown from both (a) dose response and (b) time-course analyses. Covariates along the top indicate sample treatment while (c) demonstrate the presence or absence of AHRE motifs and AHR-binding, as determined by ChIP-chip analysis