From: RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior
Number | Name | Known description, putative function or ortholog function |
---|---|---|
B30 up-regulation | ||
Secondary metabolism | ||
AFUA_3G00840 | FAD-dependent oxygenase, required for asperfuranone biosynthesis in A. nidulans (afoF) FAD-dependant oxygenase; secreted protein | |
AFUA_3G12910 | hasC | O-methyltransferase GliM-like, orthologous member of the “has” secondary metabolite biosynthetic gene cluster of strain A1163. [67] |
AFUA_3G12930 | hasE | dimethylallyl tryptophan synthase SirD-like, orthologous member of the “has” secondary metabolite biosynthetic gene cluster of strain A1163. [67] |
Transcriptional control | ||
AFUA_5G06190 | steA | sexual development transcription factor, involved in sexual development |
AFUA_5G05610 | putative cell cycle control protein Cwf14/Bud31, ortholog(s) have role in cellular bud site selection | |
AFUA_1G12940 | sakA | MAP kinase SakA, nitrogen sensing, is induced upon carbon and nitrogen starvation [52] |
Transport | ||
AFUA_1G12620 | aflT | MFS toxin efflux pump |
AFUA_7G04290 | GapA, putative amino acid transporter | |
AFUA_8G02200 | proline permease, putative amino acid transporter | |
Stress response | ||
AFUA_5G06520 | low-temperature viability protein ltv1, ortholog(s) have role in cellular response to oxidative stress, response to osmotic stress | |
AFUA_5G11230 | rasA | RAS small monomeric GTPase RasA, involved in cell wall integrity |
Chaperone and protein folding activity | ||
AFUA_2G02320 | Hsp70 chaperone (BiP) | |
AFUA_4G03650 | ribosome associated DnaJ chaperone Zuotin, | |
AFUA_8G03930 | hscA | Hsp70 chaperone HscA, Yap1-dependent induction in response to hydrogen peroxide; hypoxia induced protein |
AFUA_2G16290 | DnaJ domain protein Mas5, ortholog(s) have endoplasmic reticulum localization | |
AFUA_4G12360 | prefoldin subunit 1, has domain(s) with predicted unfolded protein binding activity, role in protein folding and prefoldin complex localization | |
Detoxification | ||
AFUA_4G12990 | trr1 | thioredoxin reductase Trr1/Trr2 |
AFUA_4G00930 | CorA family metal ion transporter, Mg transport | |
AFUA_2G13080 | Nudix/MutT family protein, ortholog(s) have hydrolase activity | |
AFUA_1G12620 | aflT | MFS toxin efflux pump |
Lipid acid and isoprenoid metabolism | ||
AFUA_8G04080 | badA | betaine aldehyde dehydrogenase, involved in glycin betain biosynthesis [45] |
AFUA_8G04090 | codA | choline oxidase, involved in glycin betain biosynthesis [45] |
B30 down-regulation | ||
Secondary metabolism: | ||
AFUA_1G10380 | nrps1 | nonribosomal peptide synthase Pes1, essential for fumigaclavine C biosynthesis [47] |
AFUA_3G03350 | sidE | nonribosomal peptide synthase SidE, involved in production of fumarylalanine [48] |
Transcription | ||
AFUA_1G12332 | jumonji family transcription factor, has domain(s) with predicted zinc ion binding activity | |
AFUA_1G13750 | C2H2 transcription factor Rpn4, proteasomal regulator in S. cervisiae | |
AFUA_1G15230 | C6 transcription factor, ortholog(s) have role in conidiophore development, conidium formation, hyphal growth | |
AFUA_1G16460 | bZIP transcription factor (LziP), ortholog(s) have role in asexual sporulation, sexual sporulation resulting in formation of a cellular spore | |
AFUA_2G11780 | CreA, C2H2 transcription factor | |
AFUA_2G13260 | medA | MedA, transcriptional regulator of adherence, host cell interactions and virulence; required for wild-type levels of conidiation |
AFUA_2G14110 | sulfur metabolite repression control protein, ortholog(s) have protein binding, bridging, ubiquitin binding activity | |
AFUA_2G14680 | flbB | Bzip developmental regulator; role in asexual development, gliotoxin production |
AFUA_2G16230 | C2H2 finger domain protein, has domain(s) with predicted DNA binding, zinc ion binding activity, role in transcription | |
AFUA_2G17220 | C2H2 transcription factor (AmdX), ortholog(s) have sequence-specific DNA binding activity, role in regulation of transcription | |
AFUA_3G02000 | farB like, C6 transcription factor Ctf1B-like, putatively involved in fatty acid degradation | |
AFUA_3G05760 | C6 transcription factor (Fcr1) | |
AFUA_3G06250 | RNA polymerase II mediator complex component, has domain(s) with predicted RNA polymerase II transcription cofactor activity | |
AFUA_3G11250 | ace2 | C2H2 transcription factor (Swi5), with a role in conidiophore development, pigment production, germination and virulence |
AFUA_3G12940 | hasF | C6 transcription factor, orthologous member of the “has” secondary metabolite biosynthetic gene cluster of strain A1163. [67] |
AFUA_4G03960 | farA | C6 transcription factor Ctf1A, with a role in beta oxidation of long-chain fatty acids |
AFUA_6G12160 | C6 transcription factor | |
Cell wall | ||
AFUA_6G06340 | gfa1 | glucosamine-fructose-6-phosphate transaminase, chitin production |
AFUA_2G01170 | gel1 | 1,3-beta-glucanosyltransferase, biosynthesis of fungal cell wall [91] |
AFUA_2G05340 | gel4 | 1,3-beta-glucanosyltransferase, GPI-anchored to the plasma membrane; cell wall maintanance |
Resistance proteins | ||
AFUA_1G03200 | mfsC | MFS transporter |
AFUA_1G10370 | MFS multidrug transporter | |
AFUA_1G10390 | abcB | ABC multidrug transporter |
AFUA_1G13800 | MFS multidrug transporter | |
AFUA_3G02610 | MFS transporter, has domain(s) with predicted role in transmembrane transport and integral to membrane localization | |
AFUA_5G00980 | MFS multidrug transporter, putative transporter of small solutes | |
AFUA_5G02700 | MFS multidrug transporter, putative transporter of small solutes | |
AFUA_7G01790 | ssu1 | MFS transporter, putative sulphite efflux pump |
AFUA_2G14570 | zinc/cadmium resistance protein, ortholog(s) have zinc ion transmembrane transporter activity, role in cellular zinc ion homeostasis | |
AFUA_6G02220 | MFS toxin efflux pump | |
AFUA_8G02050 | putative transporter of polysaccharides | |
Heat shock, chaperone activity | ||
AFUA_1G07440 | hsp70 | molecular chaperone Hsp70 |
AFUA_1G06020 | DnaJ domain protein, has domain(s) with predicted heat shock protein binding, unfolded protein binding activity and role in protein folding | |
AFUA_1G11180 | hsp78 | heat shock protein/chaperonin HSP78 |
AFUA_1G15270 | heat shock protein Hsp98/Hsp104/ClpA, ortholog(s) have cytosol, nuclear envelope localization | |
AFUA_3G14540 | hsp30 | heat shock protein Hsp30/Hsp42, putative 30-kDa heat shock protein |
AFUA_4G12850 | clxA | calnexin, ER membrane chaperone involved in folding of glycoproteins directed to the secretory pathway |
AFUA_5G07340 | DnaJ domain protein Psi, ortholog(s) have cytosol, nucleus localization, involved in protein folding and translational initiation | |
AFUA_6G06470 | heat shock protein Hsp30-like, putative integral plasma membrane heat shock protein | |
B30 up-regulation and 180 min down-regulation | ||
Protein/ peptide degradation and modification | ||
AFUA_5G06060 | skpA | sulfur metabolism regulator SkpA, part of SCF ubiquitin ligase complex |
AFUA_1G04040 | ubiA | ubiquitin |
AFUA_5G04000 | protein involved in proteasomal and 4S ribosomal subunit biogenesis | |
Peptidases | ||
AFUA_3G05450 | glutamate carboxypeptidase | |
AFUA_6G04510 | O-sialoglycoprotein endopeptidase, ortholog(s) have chromatin DNA binding activity and role in positive regulation of transcription from RNA polymerase II promoter | |
AFUA_6G07330 | methionine aminopeptidase, type I, orthologs have functions in protein processing | |
Glycosylation | ||
AFUA_6G12360 | class I alpha-mannosidase 1A, has domain(s) with predicted calcium ion binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | |
AFUA_4G10070 | class I alpha-mannosidase, has domain(s) with predicted calcium ion binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | |
AFUA_1G12630 | mannosylphosphate transferase (Mnn4), putative phosphorylcholine metabolism | |
AFUA_4G10750 | alpha-1,6-mannosyltransferase subunit, Glycan biosynthesis | |
AFUA_5G05740 | gmtA | Golgi GDP-mannose transporter, involved in biosynthesis of the cell wall polysaccharide galactomannan |
Phosphorylation | ||
AFUA_6G12820 | mpkB | MAP kinase MpkB, putative mitogen-activated protein kinase |
AFUA_5G11730 | RIO1 family protein kinase, ortholog(s) have nucleocytoplasmic transporter activity, protein kinase activity, role in maturation of SSU-rRNA | |
AFUA_1G12940 | sakA | MAP kinase SakA, nitrogen sensing, is induced upon carbon and nitrogen starvation [52] |
AFUA_1G09170 | protein kinase activator (Mob2), ortholog(s) have kinase binding activity and role in conidiophore development, hyphal growth, regulation of kinase activity | |
AFUA_1G16000 | serine/threonine protein kinase, has domain(s) with predicted ATP binding, protein tyrosine kinase activity and role in protein phosphorylation | |
AFUA_2G13680 | calcium/calmodulin-dependent protein kinase, orthologs have a function in stress response | |
AFUA_2G05490 | HEAT repeat protein, ortholog(s) have deoxyhypusine monooxygenase activity | |
AFUA_3G12490 | protein arginine methyltransferase RmtB, ortholog(s) have histone-arginine N-methyltransferase activity | |
AFUA_4G13400 | glycosyltransferase family 28, ortholog(s) have N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity | |
AFUA_5G01740 | deoxyhypusine synthase, putatively first step in hypusine biosynthesis | |
180 min down-regulation | ||
ATP binding (GO:0005524) | ||
AFUA_1G02570 | aspartyl-tRNA synthetase, cytoplasmic, aspartyl-tRNA synthetase; calcium downregulated | |
AFUA_1G05620 | phenylalanyl-tRNA synthetase, beta subunit, ortholog(s) have phenylalanine-tRNA ligase activity | |
AFUA_1G05800 | mkk2 | MAP kinase kinase (Mkk2), putative mitogen-activated protein kinase kinase (MAPKK); essential for cell wall integrity signaling; calcium induced |
AFUA_1G09010 | methionyl-tRNA synthetase, ortholog(s) have cytosol localization | |
AFUA_1G10310 | RNase L inhibitor of the ABC superfamily, ATPase, Rnase L inhibitor, orthologs involved in ribosome protection | |
AFUA_1G10630 | S-adenosylmethionine synthetase, putative S-adenosylmethionine synthetase; involved in methylation processes, biosynthesis of biotin and polyamines | |
AFUA_2G02320 | Hsp70 chaperone (BiP) | |
AFUA_2G02590 | aspartyl-tRNA synthetase Dps1 | |
AFUA_2G03580 | phenylalanyl-tRNA synthetase beta chain, ortholog(s) have phenylalanine-tRNA ligase activity | |
AFUA_2G04620 | bipA | Hsp70 chaperone BiP/Kar2 |
AFUA_2G05650 | cytoplasmic asparaginyl-tRNA synthetase, ortholog(s) have asparagine-tRNA ligase activity, role in asparaginyl-tRNA aminoacylation and cytosol localization | |
AFUA_2G06110 | chromatin remodeling and histone, ortholog(s) have role in chromatin silencing at centromere | |
AFUA_2G08670 | acetyl-CoA carboxylase, ortholog(s) have acetyl-CoA carboxylase activity, biotin carboxylase activity and role in long-chain fatty acid biosynthetic | |
AFUA_2G09290 | hsp60 | antigenic mitochondrial protein HSP60, involved in heat shock response |
AFUA_2G13140 | ime2 | meiosis induction protein kinase, a serine/threonine protein kinase involved in mycotoxin production and sex. development |
AFUA_2G14030 | arginyl-tRNA synthetase, ortholog(s) have arginine-tRNA ligase activity, role in arginyl-tRNA aminoacylation and cytosol, mitochondrion localization | |
AFUA_3G05430 | DEAD-box RNA helicase Dhh1/Vad1, ortholog(s) have translation regulator activity, nucleic acid binding activity | |
AFUA_3G08650 | C1 tetrahydrofolate synthase | |
AFUA_3G10300 | putative galactokinase with a role in galactose catabolism | |
AFUA_3G10530 | protein serine/threonine kinase (Ran1), orthologs have negative regulation of transcription/ development-meiosis | |
AFUA_3G13030 | t-complex protein 1, gamma subunit (Cct3), ortholog(s) have unfolded protein binding activity, role in cellular response to drug, protein folding | |
AFUA_4G07660 | ded1 | ATP dependent RNA helicase (Dbp1), ATP-dependent RNA helicase, cell cycle affected in S. pombe |
AFUA_4G08060 | tetrahydrofolylpolyglutamate synthase (Met7), role in one-carbon metabolic process, regulation of DNA methylation and cytosol, mitochondrion | |
AFUA_4G13700 | threonyl-tRNA synthetase, putative tRNA charging | |
AFUA_5G05490 | seryl-tRNA synthetase, | |
AFUA_5G05960 | serine/threonine protein kinase, involved in salt tolerance in S. cerevisiae | |
AFUA_5G07020 | ribosome biogenesis ABC transporter Arb1 | |
AFUA_5G09610 | cysteinyl-tRNA synthetase, putative tRNA charging | |
AFUA_5G10550 | ATP synthase F1, beta subunit, orthologs are required for synthesis of ATP, but are non-essential | |
AFUA_6G04730 | bifunctional purine biosynthetic protein Ade1, ortholog(s) have phosphoribosylamine-glycine ligase activity, phosphoribosylformylglycinamidine cyclo-ligase activity | |
AFUA_6G05080 | ABC transporter, ortholog in S. cerevisiae involved in RNA regulation and maturation | |
AFUA_6G06870 | casein kinase I homolog, ortholog(s) have magnesium ion binding, protein serine/threonine kinase activity | |
AFUA_6G07540 | t-complex protein 1, epsilon subunit, ortholog(s) have chaperonin-containing T-complex localization | |
AFUA_6G07640 | lysyl-tRNA synthetase, | |
AFUA_6G12630 | leucyl-tRNA synthetase, putative tRNA charging | |
AFUA_6G12820 | mpkB | MAP kinase MpkB, orthologs are regulating carbon utilization |
AFUA_7G05660 | translation elongation factor eEF-3 | |
Transcriptional control | ||
AFUA_2G11780 | C2H2 transcription factor (CreA) ortholog(s) have carbon catabolite repression | |
AFUA_2G13260 | medA | transcriptional regulator of adherence, host cell interactions and virulence; required for wild-type levels of conidiation |
AFUA_2G16230 | C2H2 finger domain protein, putative transcription factor, orthologs have predicted regulation of gluconeogenesis and adherence | |
AFUA_2G17220 | C2H2 transcription factor (AmdX), A. nidulans ortholog involved in regulation of acetamide catabolism; regulates amdS transcription | |
AFUA_3G08010 | ace1 | C2H2 transcription factor (Ace1), involved in cation homeostasis and in response to abiotic stress in A. nidulans |
AFUA_3G10300 | putative galactokinase ortholog in S. cerevisiae involved in conversion of alpha-D-galactose to galactose-1-phosphate, a key step in galactose catabolism | |
AFUA_3G10530 | protein serine/threonine kinase (Ran1), orthologs have negative regulation of transcription/ development-meiosis | |
AFUA_3G11250 | ace2 | C2H2 transcription factor (Swi5), role in conidiophore development, pigment production, germination and virulence |
AFUA_4G10220 | homeobox transcription factor (RfeB), ortholog(s) have role in conidiophore development, conidium formation, hyphal growth, regulation nucleotide biosynthesis | |
AFUA_4G11480 | C2H2 finger domain protein, S. cerevisiae ortholog is Zinc-regulated transcription facto | |
AFUA_4G12470 | cpcA | bZIP transcriptional activator of the cross-pathway control system of amino acid biosynthesis upon starvation |
AFUA_5G06190 | steA | putative transcription factor involved in sexual development |
AFUA_6G02110 | MADS box transcription factor Mcm1, orthologs are involved in cell cycle | |
Energy | ||
AFUA_6G12930 | acoA | aconitate hydratase, is essential for energy metabolism, TCA cycle and lysine biosynthesis [59] |
Transmembrane transport GO:0055085 | ||
AFUA_1G05020 | putative sulfate transporter | |
AFUA_2G03860 | zrfB | plasma membrane low affinity zinc ion, Low affinity plasma membrane zinc transporter; induced by zinc depletion |
AFUA_2G14570 | zinc/cadmium resistance protein, ortholog(s) have zinc ion transmembrane transporter activity, role in cellular zinc ion homeostasis | |
AFUA_3G12900 | hasB | MFS transporter, orthologous member of the “has” secondary metabolite biosynthetic gene cluster of strain A1163. [67] |
AFUA_4G14230 | MFS transporter, putative transporter of small solutes | |
AFUA_4G14670 | MFS quinate transporter, has domain(s) with predicted substrate-specific transmembrane transporter activity | |
AFUA_5G00980 | MFS multidrug transporter, putative transporter of small solutes | |
AFUA_5G02700 | MFS multidrug transporter, putative multidrug resistant protein | |
AFUA_7G01790 | ssu1 | MFS transporter, putative sulphite efflux pump |
AFUA_7G05220 | putative mitochondrial carrier protein | |
AFUA_7G05420 | mitochondrial intermembrane space protein Mia40, putatively involved in intermembrane space import | |
180 min up-regulation | ||
DNA repair | ||
AFUA_2G02090 | agt | O6-alkylguanine DNA alkyltransferase; role in DNA repair |
AFUA_3G11610 | nhp6 | nucleosome binding protein, non-histone chromosomal protein ortholog in S. cerevisiae play role in elongation and DNA repair |
Transcription factors | ||
AFUA_2G15680 | transcription initiation factor iia small chain, ortholog(s) have TBP-class protein binding, activity involved in preinitiation complex assembly activity | |
AFUA_4G03960 | farA | C6 transcription factor Ctf1A, role in beta oxidation of long-chain fatty acids |
AFUA_7G06320 | C6 transcription factor, has domain(s) with predicted DNA binding, sequence-specific DNA binding RNA polymerase II transcription factor activity | |
Protein binding, degradation, modification | ||
AFUA_5G05790 | ubiquitin ligase subunit HrtA, ring finger protein rbxA, putative E3 ubiquitin-protein ligase; NeddH-associated protein | |
AFUA_6G09160 | ubiquitin conjugating enzyme Ubc8, negatively regulates gluconeogenesis by mediating the ubiquitination of fructose-1,6-bisphosphatase [70] | |
AFUA_6G14210 | ubiquitin conjugating enzyme UbcB, ortholog(s) have ubiquitin-protein ligase activity | |
AFUA_1G07470 | atg8 | autophagic death protein atg8, ribo involved in autophagy, determines the size of the autophagosome, induced upon starvation |
Systemic interaction with the environment | ||
AFUA_4G00660 | sensor histidine kinase/response regulator, putative stress sensor | |
Nitrilases/ cyanid hydratases | ||
AFUA_6G13450 | nitrilase, ortholog(s) have cyanide hydratase activity, nitrilase activity and role in cyanide catabolic process | |
AFUA_2G17500 | cyanide hydratase/nitrilase, ortholog(s) have cyanide hydratase activity, nitrilase activity and role in cyanide catabolic process | |
Oxidation-reduction process GO:0055114 | ||
AFUA_2G10960 | adh2 | putative alcohol dehydrogenase Adh2p, in S. cerevisiae is responsible for catalyzing the initial step in the utilization of ethanol as a carbon source |
AFUA_2G11250 | aryl-alcohol dehydrogenase Aad14, unknown function | |
AFUA_2G15930 | alcohol dehydrogenase, ortholog in S. pombe role in detoxifying alcohols and related compounds, protecting against environmental stresses | |
AFUA_4G12990 | trr1 | thioredoxin reductase Trr1/Trr2, orthologs play a role in detoxification |
Iron homeostasis [12] | ||
AFUA_3G03640 | mirB | MFS siderochrome iron transporter MirB, |
AFUA_3G03440 | mirD | MFS siderophore iron transporter, expression upregulated under low iron condition |
AFUA_7G06060 | sit1 | siderochrome-iron transporter Sit1, |
AFUA_1G17270 | fre2 | FRE family ferric-chelate reductase, metalloreductase involved in response to iron starvation; reductive iron assimilation, freB |
AFUA_3G03410 | sidH | enoyl-CoA hydratase/isomerase family protein, mevalonyl-CoA hydratase; is essential for (TAFC) biosynthesis |
AFUA_3G03400 | sidF | siderophore biosynthesis acetylase AceI, hydroxyornithine transacylase; involved in extracellular siderophore biosynthesis; essential for TAFC biosynthesis |
AFUA_3G03420 | sidD | nonribosomal peptide synthase SidD, fusarinine C non-ribosomal peptide synthetase (NRPS) involved in extracellular siderophore biosynthesisthesis |
AFUA_3G03430 | sitT | ABC multidrug transporter SitT, involved in siderophore excretion |
AFUA_3G03440 | mirD | MFS siderophore iron transporter, |
AFUA_2G07680 | sidA | L-ornithine N5-oxygenase SidA, first committed step in siderophore biosynthesis; TAFC and ferricrocin biosynthesis |
Reductive iron assimilation | ||
AFUA_5G03790 | fetC | ferrooxidoreductase Fet3,; reductive iron assimilation, FetC |
AFUA_5G03800 | ftrA | high-affinity iron transporter FtrA, reductive iron assimilation, FtrA |
Gluconeogenesis | ||
AFUA_6G07720 | acuF | phosphoenolpyruvate carboxykinase AcuF, essential for gluconeogenesis |
AFUA_4G11310 | fbp1 | fructose-1,6-bisphosphatase Fbp1, essential for glucenogenesis |
AFUA_6G09160 | ubiquitin conjugating enzyme Ubc8, n negatively regulates gluconeogenesis by mediating the ubiquitination of fructose-1,6-bisphosphatase [70] |