Table 7 Cross-species differentially expressed genes with known phenotypic effect

nme2b.2

NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2

SM

4

GTP biosynthesis

ZFIN

prkcg

protein kinase C, gamma

EO

1

AMPA-R kinetics

ZFIN

aco2

aconitase 2, mitochondrial

EO

2

Infantile cerebellar-retinal degeneration

OMIM

pdp1

pyruvate dehyrogenase phosphatase catalytic subunit 1

EO

2

Pyruvate dehydrogenase phosphatase deficiency

OMIM

nnt

nicotinamide nucleotide transhydrogenase

EO

2

Glucocorticoid deficiency 4

OMIM

sucla2

succinate-CoA ligase, ADP-forming, beta subunit

EO

2

Mitochondrial DNA depletion syndrome 5

OMIM

kcnj11

potassium inwardly-rectifying channel, subfamily J, member 11

EO

2

Diabetes mellitus

OMIM

ippk

inositol 1,3,4,5,6-pentakisphosphate 2-kinase

EO

2

Craniofacial development

ZFIN

smpd1

sphingomyelin phosphodiesterase 1, acid lysosomal

EO

2

Niemann-Pick disease

OMIM

th

tyrosine hydroxylase

EO

2

Adult brain function

ZFIN

ache

acetylcholinesterase

EO

2

Locomotion

ZFIN

oxct1a

3-oxoacid CoA transferase 1a

EO

2

Succinyl CoA:3-oxoacid CoA transferase deficiency

OMIM

mlycd

malonyl-CoA decarboxylase

EO

2

Malonyl-CoA decarboxylase deficiency

OMIM

idh1

isocitrate dehydrogenase 1 (NADP+), soluble

EO

2

Susceptibility to glioma

OMIM

cpt2

carnitine palmitoyltransferase 2

EO

2

Myopathy/Encephalopathy

OMIM

pltp

phospholipid transfer protein

EO

2

HDL cholesterol level

OMIM

acat1

acetyl-CoA acetyltransferase 1

EO

2

Alpha-methylacetoacetic aciduria

OMIM

atp1a1a.1

ATPase, Na+/K+ transporting, alpha 1a polypeptide, tandem duplicate 1

EO

3

Brain development

ZFIN

ryr1a

ryanodine receptor 1a (skeletal)

EO

3

Myopathy

ZFIN

bcl2l10

BCL2-like 10 (apoptosis facilitator)

EO

3

Cytoskeletal activity

ZFIN

nalcn

sodium leak channel, non-selective

EO

3

Hypotonia

OMIM

cngb1a

cyclic nucleotide gated channel beta 1a

EO

3

Retinitis pigmentosa 45

OMIM

kcnma1a

potassium large conductance calcium-activated channel, subfamily M, alpha member 1a

EO

3

Hearing sensitivity

ZFIN

kcnq5b

potassium voltage-gated channel, KQT-like subfamily, member 5b

EO

3

Cell membrane excitability

ZFIN

nsfa

N-ethylmaleimide-sensitive factor a

EO

3

Axon development

ZFIN

chrna4b

cholinergic receptor, nicotinic, alpha 4b

EO

3

Epilepsy

OMIM

adcy1b

adenylate cyclase 1b

EO

3

Deafness

OMIM

actn2b

actinin, alpha 2b

EO

3

Cardiomyopathy

OMIM

vmhc

ventricular myosin heavy chain

EO

3

Cardiomyopathy

OMIM