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Table 5 Pathway enrichment analysis of potential target genes in HN1957 for miRNAs responding to therapy in HNSCC patients (FDR < 0.05)

From: Integrative analysis of the microRNA-mRNA response to radiochemotherapy in primary head and neck squamous cell carcinoma cells

Pathway Number of Proteins in Pathway Proteins from Gene List P-value FDR Genes
Pathways in cancer (K) 327 7 0.0004 1.40E-02 E2F1,PTEN,AKT2,MSH6,HSP90AA1,JUN,VEGFA
Direct p53 effectors (N) 133 5 0.0002 1.40E-02 E2F1,PTEN,SP1,JUN,SMARCA4
Hepatitis B (K) 146 5 0.0004 1.38E-02 E2F1,PTEN,AKT2,JUN,YWHAQ
Nonsense-mediated decay (R) 106 5 0.0001 1.55E-02 RPL30,UPF1,SMG7,RNPS1,RPL18A
RNA transport (K) 164 5 0.0006 1.50E-02 EEF1A1,UPF1,RNPS1,EIF4G2,NUP205
E2F transcription factor network (N) 68 4 0.0002 1.44E-02 E2F1,KAT2B,SP1,RRM2
Estrogen signaling pathway (K) 100 4 0.0009 1.69E-02 AKT2,HSP90AA1,SP1,JUN
Glucocorticoid receptor regulatory network (N) 77 4 0.0003 1.34E-02 SMARCD1,HSP90AA1,JUN,SMARCA4
HIF-1-alpha transcription factor network (N) 66 4 0.0002 2.03E-02 NPM1,SP1,JUN,VEGFA
Huntington disease (P) 121 4 0.0017 2.79E-02 GAPDH,AKT2,AP2A2,JUN
Processing of capped intron-containing pre-mRNA (R) 138 4 0.0028 3.33E-02 DDX23,PCBP1,RNPS1,NUP205
Prostate cancer (K) 89 4 0.0006 1.56E-02 E2F1,PTEN,AKT2,HSP90AA1
Regulation of androgen receptor activity (N) 49 4 0.0001 1.70E-02 KAT7,HSP90AA1,KAT2B,JUN
Regulation of telomerase (N) 68 4 0.0002 1.44E-02 E2F1,HSP90AA1,SP1,JUN
  1. (B) BioCarta, (K) KEGG Pathway, (N) NCI - Nature Curated Data, (P) pantherdb, (R) Reactome