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Fig. 6 | BMC Genomics

Fig. 6

From: Malat1 as an evolutionarily conserved lncRNA, plays a positive role in regulating proliferation and maintaining undifferentiated status of early-stage hematopoietic cells

Fig. 6

p53 regulated the expression of Malat1 via sequence specific binding. a CHIP assay showed p53 protein bound to BS-p53-1 but BS-p53-2 site, the means ± SD of three independent experiments are shown, P < 0.05 vs Mock control (co-immunoprecipitated with rabbit IgG). b Schematic drawing shows the sequence specific binding of repression. The BS-p53-1 site with conserved sequence of cGGCATG has strong p53 binding activity therefore inhibits Malat1 expression

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BMC Genomics

ISSN: 1471-2164

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