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Table 4 Univariate and Multivariate results for overall survival (Discovery cohort)

From: Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer

A. Case–control approach

Parameter

Univariate analysis

Multivariate analysis

HR (95 % CI)

p-value

HR (95 % CI)

p-value

Risk score

2.44 (1.28 – 4.68)

0.01

2.71 (1.38 – 5.35)

0.004

Tumor stage

0.42 (0.22 – 0.81)

0.01

0.36 (0.18 – 0.74)

0.01

Tumor grade

1.93 (0.99 – 3.75)

0.05

  

Age at diagnosis

1.05 (1.02 – 1.09)

0.003

1.04 (1.01 – 1.07)

0.02

TNBC status

0.88 (0.43 – 1.77)

0.71

  

B. Case-only approach

Parameter

Univariate analysis

Multivariate analysis

HR (95 % CI)

p-value

HR (95 % CI)

p-value

Risk score

2.48 (1.34 – 4.61)

0.004

2.76 (1.47 – 5.19)

0.002

Tumor stage

0.42 (0.22 – 0.81)

0.01

0.37 (0.19 – 0.72)

0.004

Tumor grade

1.93 (0.995 – 3.75)

0.05

  

Age at diagnosis

1.05 (1.02 – 1.09)

0.003

  

TNBC status

0.88 (0.43 – 1.77)

0.71

  
  1. A and B: The four and 11 miRNAs from Table 1A and B respectively were used to construct risk scores. Receiver Operating Characteristics Curve was used to dichotomize cases into low and high-risk groups. Univariate Cox proportional hazards regression model was run for risk score and for other clinical parameters. In the multivariate analysis, risk score was significant with p < 0.05 after adjusting for confounders.
  2. HR Hazard Ratio; CI Confidence Interval; TNBC Triple Negative Breast Cancer
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BMC Genomics

ISSN: 1471-2164

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