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Table 7 Univariate and multivariate results for overall survival (External Validation cohort/TCGA)

From: Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer

Parameter Univariate analysis Multivariate analysis
HR (95 % CI) p-value HR (95 % CI) p-value
Risk score 2.16 (0.92 – 5.05) 0.08 2.07 (0.87 – 4.92) 0.101
Tumor stage 0.32 (0.13 – 0.78) 0.01 0.26 (0.1 – 0.67) 0.005
Age at diagnosis 1.03 (1.003 – 1.06) 0.03   
TNBC status 0.63 (0.19 – 2.12) 0.46   
  1. The eleven miRNAs identified as significant for OS in CO approach from the discovery set was validated using TCGA dataset. Risk score was constructed using the 11 miRNAs and an optimal cut-off point was estimated using Receiver Operating Characteristics Curve, which dichotomized the samples into low and high-risk groups. Univariate Cox proportional hazards regression model was run for risk score and for other clinical parameters. In the multivariate analysis, risk score was significant with p = 0.1 after adjusting for tumor stage.
  2. HR Hazard Ratio; CI Confidence Interval; TNBC Triple Negative Breast Cancer