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Fig. 3 | BMC Genomics

Fig. 3

From: Helveticoside is a biologically active component of the seed extract of Descurainia sophia and induces reciprocal gene regulation in A549 human lung cancer cells

Fig. 3

Dose-dependent gene expression after EEDS or helveticoside treatment in A549 cells. a Approximately 5,800 genes were differentially expressed over two-fold in at least one sample when compared with the vehicle control group. For comparison, the expression levels of genes induced by the top-ranked 15 chemicals selected from the Connectivity map analysis of EEDS are also displayed in parallel. The columns and rows represent individual samples and genes, respectively. The expression ratio color scale ranges from red (high) to green (low) as indicated by the scale bar. b The dose-dependently regulated genes affected by helveticoside treatment were identified with the STEM program (FDR < 0.001). The down-regulated pattern was composed of 1,093 genes, and the up-regulated pattern was composed of 824 genes.

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BMC Genomics

ISSN: 1471-2164

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