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Fig. 4 | BMC Genomics

Fig. 4

From: Helveticoside is a biologically active component of the seed extract of Descurainia sophia and induces reciprocal gene regulation in A549 human lung cancer cells

Fig. 4

Comparison of connectivity scores between EEDS and helveticoside. a The 25 top-ranked drugs (permutated p-value < 0.0001) were selected from the Connectivity map analysis of helveticoside-treated A549 cells, in which 126 genes were up-regulated (over 4-fold) and 151 genes were down-regulated (under 0.25-fold). The connectivity scores were then compared with those obtained from the EEDS-treated A549 cells. The list of drugs is ordered according to the rank obtained from the Connectivity map analysis of helveticoside-treated A549 cells. b The correlation of the connectivity scores between EEDS and helveticoside was measured.

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BMC Genomics

ISSN: 1471-2164

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