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Table 2 Pathways enriched (FDR < 0.01) by helveticoside

From: Helveticoside is a biologically active component of the seed extract of Descurainia sophia and induces reciprocal gene regulation in A549 human lung cancer cells

Pattern

KEGG ID

Name

p-value*

FDRa

Down-regulation

NA

NA

NA

NA

Up-regulation

hsa4010

MAPK signaling pathway

8.00E-07

1.10E-04

 

hsa4350

TGF-beta signaling pathway

4.73E-06

3.25E-04

 

hsa4710

Circadian rhythm

2.27E-05

1.03E-03

 

hsa4210

Apoptosis

7.98E-05

2.71E-03

 

hsa5200

Pathways in cancer

8.00E-05

2.18E-03

 

hsa4540

Gap junction

8.86E-05

2.01E-03

 

hsa5212

Pancreatic cancer

2.05E-04

3.96E-03

 

hsa4060

Cytokine-cytokine receptor interaction

2.50E-04

4.22E-03

 

hsa5219

Bladder cancer

3.39E-04

5.07E-03

 

hsa4115

p53 signaling pathway

4.73E-04

6.33E-03

 

hsa4660

T cell receptor signaling pathway

5.15E-04

6.27E-03

 

hsa5221

Acute myeloid leukemia

5.31E-04

5.94E-03

 

hsa5211

Renal cell carcinoma

5.74E-04

5.93E-03

 

hsa4110

Cell cycle

6.00E-04

5.76E-03

 

hsa4621

NOD-like receptor signaling pathway

8.03E-04

7.15E-03

 

hsa4662

B cell receptor signaling pathway

9.02E-04

7.52E-03

  1. *p-values were calculated using the Fischer’s test
  2. aFDR corrections were calculated using the Benjamini-Hochberg procedure