Fig. 5
From: Functional development of the adult ovine mammary gland—insights from gene expression profiling
Genes involved in protein processing are differentially regulated between late pregnancy and lactation. Model of the networks of genes potentially involved in the regulation of protein processing in the late pregnant (day 135 of pregnancy ± 2.4 SD, n = 27) and lactating (day 15 post-partum ± 1.27 SD, n = 18) ovine mammary gland, as measured by RNA-seq. Genes shown in red, highlighted that protein translation was down-regulated (genes > 2-fold change in expression, RPKM P < 0.05) during lactation, compared with late pregnancy. Genes shown in blue highlighted that protein processing pathways, particularly the Endoplasmic Reticulum Associated Degradation (ERAD) and the unfolded protein response pathways, were enriched (genes > 2-fold change in expression, RPKM P < 0.05,) during lactation, compared with late pregnancy. Genes shown in black denotes no significant change in expression (RPKM P > 0.05) between late pregnancy and lactation