Table 1 Predicted venom proteome of potential toxins from the translated genome sequence of Acropora digitifera
A. digitifera protein accession number | Predicted biological effect | Sequence homology (e-value) | Uniprot accession number | Toxin with closest homology | Example of animal species with closest homology |
|---|---|---|---|---|---|
adi_v1.16452 | Cytolysin | 5.00E-55 | J3SBP3 | Phosphodiesterase | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.02125 | Cytolysin | 2.0E-137 | J3SBP3 | Phosphodiesterase | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.08969 | Cytolysin | 1.0E-76 | F8J2D3 | Phospholipase-B | Drysdalia coronoides (White-lipped snake) |
adi_v1.12172 | Cytolysin | 4.0E-121 | F8J2D3 | Phospholipase-B | Drysdalia coronoides (White-lipped snake) |
adi_v1.14353 | Cytolysin | 2.0E-83 | [43] | Δ-ALTX-Pse | Phyllodiscus semoni (Night sea anemone) |
adi_v1.09427 | Cytolysin | 7.0E-93 | [43] | Δ-TATX-Avl2a | Actineria villosa (Okinawan sea anemone) |
adi_v1.16619 | Cytolysin | 3.00E-88 | [43] | Δ-TATX-Avl2a | Actineria villosa (Okinawan sea anemone) |
adi_v1.16440 | Cytolysin | 1.00E-12 | [43] | Δ-AITX-Aas1a (Bandaporin) | Anthopleura asiatica (Giant green sea anemone) |
adi_v1.24162 | Cytolysin | 3.00E-11 | P61914 | Equinatoxin-2 (Actinoporin) | Actinia equina (Beadlet sea anemone) |
adi_v1.04835 | Cytolysin | 2.0E-120 | J3SDX8 | Lipase | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.23821 | Cytolysin | 3.00E-101 | J3SDX8 | Lipase | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.01810 | Cytolysin | 7.0E-65 | J3SDX8 | Lipase | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.09322 | Cytolysin | 4.0E-47 | J3RZ81 | Lipase | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.00020 | Cytolysin | 1.0E-39 | J3RZ81 | Lipase | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.12434 | Cytolysin | 1.00E-43 | A2VBC4 | Phospholipase A1 | Polybia paulista (Neotropical social wasp) |
adi_v1.09601 | Cytolysin | 2.0E-16 | Q93109 | Equinatoxin-5 (Actinoporin) | Actinia equina (Beadlet sea anemone) |
adi_v1.10410 | Cytolysin | 4.0E-52 | Reference [43] | Δ-AITX-Ucs1a (Urticinatoxin) | Urticina crassicornis (Christmas sea anemone) |
adi_v1.12125 | Cytolysin | 2.00E-26 | J3S836 | Phosphodiesterase | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.06821 | Cytolysin | 2.0E-78 | A3QVN9 | Hyaluronidase | Bitis arietans (African puff adder) |
adi_v1.16469 | Cytolysin | 5.00E-13 | P81383 | L-amino-acid oxidase | Ophiophagus hannah (King cobra) |
adi_v1.12311 | Cytolysin | 2.0E-16 | A7L035 | Toxin CfTX-1 | Chironex fleckeri (Box jellyfish) |
adi_v1.16921 | Disrupts haemostasis | 3.00E-28 | D2X8K2 | Phospholipase A2 | Condylactis gigantea (Giant Caribbean sea anemone) |
adi_v1.16374 | Disrupts haemostasis | 8.0E-32 | Q58L94 | Prothrombin activator (Notecarin) | Notechis scutatus scutatus (Tiger snake) |
adi_v1.15821 | Disrupts haemostasis | 5.0E-41 | Q4QXT9 | Coagulation factor X | Tropidechis carinatus (Rough scaled snake) |
adi_v1.08904 | Disrupts haemostasis | 5.0E-35 | Q76B45 | Serine-type endopeptidase (Blarina toxin) | Blarina brevicauda (Northern short-tailed shrew) |
adi_v1.19445 | Disrupts haemostasis | 8.0E-112 | C6JUN2 | Metalloprotease (SVMP) | Philodryas olfersii (Green snake) |
adi_v1.14946 | Disrupts haemostasis | 1.0E-30 | B6EWW8 | Snake venom 5’-nucleotidase | Gloydius brevicaudus (Korean slamosa snake) |
adi_v1.12298 | Disrupts haemostasis | 4.0E-15 | Q4PRC6 | Snaclec 7 | Daboia siamensis (Eastern Russel’s viper) |
adi_v1.18989 | Disrupts haemostasis | 6.00E-08 | Q66S13 | Fish venom Natterin-4 | Thalassophryne nattereri (Niquim) |
adi_v1.19802 | Disrupts haemostasis | 1.0E-19 | A7X3Z0 | C-type lectin (Lectoxin-Thr1) | Thrasops jacksonii (Jackson’s black tree snake) |
adi_v1.06850 | Disrupts haemostasis | 9.0E-16 | A8QZJ5 | Cytotoxin-1 | Millepora dichotoma (Net fire coral) |
adi_v1.22096 | Disrupts haemostasis | 2.00E-68 | D8VNT0 | Ryncolin-4 | Cerberus rynchops (Dog-faced water snake) |
adi_v1.19322 | Induces immune response | 4.0E-19 | P35779 | Venom allergen 3 | Solenopsis richteri (Black imported fire ant) |
adi_v1.01092 | Induces immune response | 5.0E-36 | J3SFJ3 | Translationally-controlled tumor protein homolog | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.11797 | Neurotoxin | 3.0E-30 | P00615 | Phospholipase A2 | Oxyuranus scutellatus scutellatus (Australian taipan) |
adi_v1.18628 | Neurotoxin | 8.0E-15 | Q9TWL9 | Phospholipase A2 (Conodipine-M) | Conus magus (Magician’s cone snail) |
adi_v1.05505 | Peptidase | 1.0E-41 | C9WMM5 | Serine carboxypeptidase | Apis mellifera (Honeybee) |
adi_v1.05180 | Peptidase | 7.0E-52 | B2D0J5 | Serine carboxypeptidase | Apis mellifera (Honeybee) |
adi_v1.11218 | Proteinase inhibitor | 3.0E-17 | Q6ITB9 | Kunitz-type serine protease inhibitor (Mulgin-3) | Pseudechis australis (King brown snake) |
adi_v1.23374 | Proteinase inhibitor | 8.0E-17 | P0C8W3 | Kunitz-type serine protease inhibitor (Hg1) | Hadrurus gertschi (Desert hairy scorpion) |
adi_v1.09855 | Unknown | 3.0E-136 | B2DCR8 | SE-cephalotoxin | Sepia esculenta (Golden cuttlefish) |
adi_v1.20368 | Venom maturation | 2.0E-51 | K7Z9Q9 | Metalloprotease (Nematocyte expressed protein 6) | Nematostella vectensis (Starlet sea anemone) |
adi_v1.17845 | Venom maturation | 3.0E-44 | K7Z9Q9 | Metalloprotease (Nematocyte expressed protein 6) | Nematostella vectensis (Starlet sea anemone) |
adi_v1.13648 | Venom maturation | 4.0E-38 | K7Z9Q9 | Metalloprotease (Nematocyte expressed protein 6) | Nematostella vectensis (Starlet sea anemone) |
adi_v1.07444 | Venom maturation | 1.0E-28 | C9D7R3 | Metalloprotease (Astacin-like toxin) | Loxosceles intermedia (Brown spider) |
adi_v1.23604 | Venom maturation | 3.0E-21 | C9D7R2 | Metalloprotease (Astacin-like toxin) | Loxosceles intermedia (Brown spider) |
adi_v1.15751 | Venom maturation | 7.00E-37 | A0FKN6 | Metalloprotease (Astacin-like toxin) | Loxosceles intermedia (Brown spider) |
adi_v1.20292 | Venom maturation | 5.0E-28 | B1A4F7 | Venom dipeptidyl peptidase 4 | Vespula vulgaris (Yellow jacket wasp) |
adi_v1.15074 | Venom maturation | 2.0E-28 | B1A4F7 | Venom dipeptidyl peptidase 4 | Vespula vulgaris (Yellow jacket wasp) |
adi_v1.09733 | Venom maturation | 9.0E-29 | Q9TXD8 | Serine type endopeptidase | Agelenopsis aperta (North American funnel-web spider) |
adi_v1.03437 | Venom maturation | 6.0E-13 | Q3SB11 | Calglandulin | Tropidechis carinatus (Australian rough-scaled snake) |
adi_v1.01102 | Venom maturation | 5.0E-38 | Q3SB11 | Calglandulin | Tropidechis carinatus (Australian rough-scaled snake) |
adi_v1.05162 | Venom maturation | 1.0E-47 | J3S9D9 | Phospholipase A2 activation (Reticulocalbin-2) | Crotalus adamanteus (Eastern diamondback rattlesnake) |
adi_v1.10508 | Venom maturation | 5.0E-53 | Q8MMH3 | Protein-glutamate O-methyltransferase | Pimpla hypochondriaca (Parasitoid wasp) |