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Table 1 Predicted venom proteome of potential toxins from the translated genome sequence of Acropora digitifera

From: Gene duplications are extensive and contribute significantly to the toxic proteome of nematocysts isolated from Acropora digitifera (Cnidaria: Anthozoa: Scleractinia)

A. digitifera protein accession number Predicted biological effect Sequence homology (e-value) Uniprot accession number Toxin with closest homology Example of animal species with closest homology
adi_v1.16452 Cytolysin 5.00E-55 J3SBP3 Phosphodiesterase Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.02125 Cytolysin 2.0E-137 J3SBP3 Phosphodiesterase Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.08969 Cytolysin 1.0E-76 F8J2D3 Phospholipase-B Drysdalia coronoides (White-lipped snake)
adi_v1.12172 Cytolysin 4.0E-121 F8J2D3 Phospholipase-B Drysdalia coronoides (White-lipped snake)
adi_v1.14353 Cytolysin 2.0E-83 [43] Δ-ALTX-Pse Phyllodiscus semoni (Night sea anemone)
adi_v1.09427 Cytolysin 7.0E-93 [43] Δ-TATX-Avl2a Actineria villosa (Okinawan sea anemone)
adi_v1.16619 Cytolysin 3.00E-88 [43] Δ-TATX-Avl2a Actineria villosa (Okinawan sea anemone)
adi_v1.16440 Cytolysin 1.00E-12 [43] Δ-AITX-Aas1a (Bandaporin) Anthopleura asiatica (Giant green sea anemone)
adi_v1.24162 Cytolysin 3.00E-11 P61914 Equinatoxin-2 (Actinoporin) Actinia equina (Beadlet sea anemone)
adi_v1.04835 Cytolysin 2.0E-120 J3SDX8 Lipase Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.23821 Cytolysin 3.00E-101 J3SDX8 Lipase Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.01810 Cytolysin 7.0E-65 J3SDX8 Lipase Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.09322 Cytolysin 4.0E-47 J3RZ81 Lipase Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.00020 Cytolysin 1.0E-39 J3RZ81 Lipase Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.12434 Cytolysin 1.00E-43 A2VBC4 Phospholipase A1 Polybia paulista (Neotropical social wasp)
adi_v1.09601 Cytolysin 2.0E-16 Q93109 Equinatoxin-5 (Actinoporin) Actinia equina (Beadlet sea anemone)
adi_v1.10410 Cytolysin 4.0E-52 Reference [43] Δ-AITX-Ucs1a (Urticinatoxin) Urticina crassicornis (Christmas sea anemone)
adi_v1.12125 Cytolysin 2.00E-26 J3S836 Phosphodiesterase Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.06821 Cytolysin 2.0E-78 A3QVN9 Hyaluronidase Bitis arietans (African puff adder)
adi_v1.16469 Cytolysin 5.00E-13 P81383 L-amino-acid oxidase Ophiophagus hannah (King cobra)
adi_v1.12311 Cytolysin 2.0E-16 A7L035 Toxin CfTX-1 Chironex fleckeri (Box jellyfish)
adi_v1.16921 Disrupts haemostasis 3.00E-28 D2X8K2 Phospholipase A2 Condylactis gigantea (Giant Caribbean sea anemone)
adi_v1.16374 Disrupts haemostasis 8.0E-32 Q58L94 Prothrombin activator (Notecarin) Notechis scutatus scutatus (Tiger snake)
adi_v1.15821 Disrupts haemostasis 5.0E-41 Q4QXT9 Coagulation factor X Tropidechis carinatus (Rough scaled snake)
adi_v1.08904 Disrupts haemostasis 5.0E-35 Q76B45 Serine-type endopeptidase (Blarina toxin) Blarina brevicauda (Northern short-tailed shrew)
adi_v1.19445 Disrupts haemostasis 8.0E-112 C6JUN2 Metalloprotease (SVMP) Philodryas olfersii (Green snake)
adi_v1.14946 Disrupts haemostasis 1.0E-30 B6EWW8 Snake venom 5’-nucleotidase Gloydius brevicaudus (Korean slamosa snake)
adi_v1.12298 Disrupts haemostasis 4.0E-15 Q4PRC6 Snaclec 7 Daboia siamensis (Eastern Russel’s viper)
adi_v1.18989 Disrupts haemostasis 6.00E-08 Q66S13 Fish venom Natterin-4 Thalassophryne nattereri (Niquim)
adi_v1.19802 Disrupts haemostasis 1.0E-19 A7X3Z0 C-type lectin (Lectoxin-Thr1) Thrasops jacksonii (Jackson’s black tree snake)
adi_v1.06850 Disrupts haemostasis 9.0E-16 A8QZJ5 Cytotoxin-1 Millepora dichotoma (Net fire coral)
adi_v1.22096 Disrupts haemostasis 2.00E-68 D8VNT0 Ryncolin-4 Cerberus rynchops (Dog-faced water snake)
adi_v1.19322 Induces immune response 4.0E-19 P35779 Venom allergen 3 Solenopsis richteri (Black imported fire ant)
adi_v1.01092 Induces immune response 5.0E-36 J3SFJ3 Translationally-controlled tumor protein homolog Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.11797 Neurotoxin 3.0E-30 P00615 Phospholipase A2 Oxyuranus scutellatus scutellatus (Australian taipan)
adi_v1.18628 Neurotoxin 8.0E-15 Q9TWL9 Phospholipase A2 (Conodipine-M) Conus magus (Magician’s cone snail)
adi_v1.05505 Peptidase 1.0E-41 C9WMM5 Serine carboxypeptidase Apis mellifera (Honeybee)
adi_v1.05180 Peptidase 7.0E-52 B2D0J5 Serine carboxypeptidase Apis mellifera (Honeybee)
adi_v1.11218 Proteinase inhibitor 3.0E-17 Q6ITB9 Kunitz-type serine protease inhibitor (Mulgin-3) Pseudechis australis (King brown snake)
adi_v1.23374 Proteinase inhibitor 8.0E-17 P0C8W3 Kunitz-type serine protease inhibitor (Hg1) Hadrurus gertschi (Desert hairy scorpion)
adi_v1.09855 Unknown 3.0E-136 B2DCR8 SE-cephalotoxin Sepia esculenta (Golden cuttlefish)
adi_v1.20368 Venom maturation 2.0E-51 K7Z9Q9 Metalloprotease (Nematocyte expressed protein 6) Nematostella vectensis (Starlet sea anemone)
adi_v1.17845 Venom maturation 3.0E-44 K7Z9Q9 Metalloprotease (Nematocyte expressed protein 6) Nematostella vectensis (Starlet sea anemone)
adi_v1.13648 Venom maturation 4.0E-38 K7Z9Q9 Metalloprotease (Nematocyte expressed protein 6) Nematostella vectensis (Starlet sea anemone)
adi_v1.07444 Venom maturation 1.0E-28 C9D7R3 Metalloprotease (Astacin-like toxin) Loxosceles intermedia (Brown spider)
adi_v1.23604 Venom maturation 3.0E-21 C9D7R2 Metalloprotease (Astacin-like toxin) Loxosceles intermedia (Brown spider)
adi_v1.15751 Venom maturation 7.00E-37 A0FKN6 Metalloprotease (Astacin-like toxin) Loxosceles intermedia (Brown spider)
adi_v1.20292 Venom maturation 5.0E-28 B1A4F7 Venom dipeptidyl peptidase 4 Vespula vulgaris (Yellow jacket wasp)
adi_v1.15074 Venom maturation 2.0E-28 B1A4F7 Venom dipeptidyl peptidase 4 Vespula vulgaris (Yellow jacket wasp)
adi_v1.09733 Venom maturation 9.0E-29 Q9TXD8 Serine type endopeptidase Agelenopsis aperta (North American funnel-web spider)
adi_v1.03437 Venom maturation 6.0E-13 Q3SB11 Calglandulin Tropidechis carinatus (Australian rough-scaled snake)
adi_v1.01102 Venom maturation 5.0E-38 Q3SB11 Calglandulin Tropidechis carinatus (Australian rough-scaled snake)
adi_v1.05162 Venom maturation 1.0E-47 J3S9D9 Phospholipase A2 activation (Reticulocalbin-2) Crotalus adamanteus (Eastern diamondback rattlesnake)
adi_v1.10508 Venom maturation 5.0E-53 Q8MMH3 Protein-glutamate O-methyltransferase Pimpla hypochondriaca (Parasitoid wasp)