Fig. 9
From: Changes in correlation between promoter methylation and gene expression in cancer
Association between predictive power of methylation and CNVs. Panel a Predictive power distribution using either CNV data only with least squares, DNA methylation data only with lasso regression or both CNV and DNA methylation data with lasso regression. Combined methylation and CNV information yield significantly higher predictive power (P< 10−16). Panel b Scatterplot of predictive power using DNA methylation only and copy number information only shows that both regulation mechanisms operate exclusively on genes (R 2=6×10−4)