Fig. 1

Artemisinin and derivative drug (ART) response from microarray data analysis. a. Heatmap of genes with significant changes in expression (547 genes FDR < 0.05) by RankProducts meta-analysis of microarray data for artemisinin [5], artesunate [4] and DHA (this study) induced changes. Rows correspond to genes and columns parasite drug treatments. The values used for clustering are the average of treatment replicates, or the average of multiple probe measurements for the same gene (Hu et al. data [5]). Columns and rows were ordered by hierarchical clustering; the row dendrogram is omitted for clarity. Treatments cluster according to drug derivative/microarray study, as shown by side bars. b. Correlation of DHA-induced transcriptional changes (1, 2 and 3 h treatments) in P. falciparum K1 strain with HB3 strain intra-erythrocytic developmental cycle changes over 46 time-points of hours post-invasion (hpi) [31]. Pearson correlation coefficients (PCC) were calculated from 4157 shared oligo probe features