Table 1 Gene Ontology analysis of genes down-regulated in response to DHA in P. falciparum K1 rings from RNA-seq analysis
Term | Count | List Total | Pop Hits | Pop Total | PValue | FDR |
|---|---|---|---|---|---|---|
GO:0006412 ~ translation | 70 | 151 | 168 | 1076 | 1.5E–22 | 2.0E–19 |
GO:0044445 ~ cytosolic part | 38 | 115 | 61 | 869 | 3.8E–20 | 4.3E–17 |
GO:0005840 ~ ribosome | 48 | 115 | 108 | 869 | 8.3E–18 | 9.2E–15 |
GO:0005829 ~ cytosol | 42 | 115 | 84 | 869 | 1.3E–17 | 1.4E–14 |
GO:0003735 ~ structural constituent of ribosome | 44 | 184 | 96 | 1289 | 2.4E–14 | 3.0E–11 |
GO:0030529 ~ ribonucleoprotein complex | 52 | 115 | 150 | 869 | 7.4E–14 | 8.2E–11 |
GO:0005198 ~ structural molecule activity | 44 | 184 | 115 | 1289 | 4.8E–11 | 6.1E–08 |
GO:0043228 ~ non-membrane-bounded organelle | 49 | 115 | 167 | 869 | 8.7E–10 | 9.6E–07 |
GO:0022627 ~ cytosolic small ribosomal subunit | 16 | 115 | 22 | 869 | 1.9E–09 | 2.1E–06 |
GO:0015935 ~ small ribosomal subunit | 19 | 115 | 35 | 869 | 2.5E–08 | 2.8E–05 |
GO:0008135 ~ translation factor activity, nucleic acid binding | 17 | 184 | 47 | 1289 | 3.8E–04 | 4.8E–01 |
GO:0006006 ~ glucose metabolic process | 10 | 151 | 20 | 1076 | 6.7E–04 | 9.1E–01 |
GO:0016052 ~ carbohydrate catabolic process | 10 | 151 | 21 | 1076 | 1.0E–03 | 1.4E + 00 |
GO:0044275 ~ cellular carbohydrate catabolic process | 10 | 151 | 21 | 1076 | 1.0E–03 | 1.4E + 00 |
GO:0046164 ~ alcohol catabolic process | 10 | 151 | 21 | 1076 | 1.0E–03 | 1.4E + 00 |
GO:0005853 ~ eukaryotic translation elongation factor 1 complex | 5 | 115 | 5 | 869 | 1.3E–03 | 1.4E + 00 |
GO:0019318 ~ hexose metabolic process | 10 | 151 | 22 | 1076 | 1.6E–03 | 2.1E + 00 |