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Table 1 Gene Ontology analysis of genes down-regulated in response to DHA in P. falciparum K1 rings from RNA-seq analysis

From: Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

Term Count List Total Pop Hits Pop Total PValue FDR
GO:0006412 ~ translation 70 151 168 1076 1.5E–22 2.0E–19
GO:0044445 ~ cytosolic part 38 115 61 869 3.8E–20 4.3E–17
GO:0005840 ~ ribosome 48 115 108 869 8.3E–18 9.2E–15
GO:0005829 ~ cytosol 42 115 84 869 1.3E–17 1.4E–14
GO:0003735 ~ structural constituent of ribosome 44 184 96 1289 2.4E–14 3.0E–11
GO:0030529 ~ ribonucleoprotein complex 52 115 150 869 7.4E–14 8.2E–11
GO:0005198 ~ structural molecule activity 44 184 115 1289 4.8E–11 6.1E–08
GO:0043228 ~ non-membrane-bounded organelle 49 115 167 869 8.7E–10 9.6E–07
GO:0022627 ~ cytosolic small ribosomal subunit 16 115 22 869 1.9E–09 2.1E–06
GO:0015935 ~ small ribosomal subunit 19 115 35 869 2.5E–08 2.8E–05
GO:0008135 ~ translation factor activity, nucleic acid binding 17 184 47 1289 3.8E–04 4.8E–01
GO:0006006 ~ glucose metabolic process 10 151 20 1076 6.7E–04 9.1E–01
GO:0016052 ~ carbohydrate catabolic process 10 151 21 1076 1.0E–03 1.4E + 00
GO:0044275 ~ cellular carbohydrate catabolic process 10 151 21 1076 1.0E–03 1.4E + 00
GO:0046164 ~ alcohol catabolic process 10 151 21 1076 1.0E–03 1.4E + 00
GO:0005853 ~ eukaryotic translation elongation factor 1 complex 5 115 5 869 1.3E–03 1.4E + 00
GO:0019318 ~ hexose metabolic process 10 151 22 1076 1.6E–03 2.1E + 00
  1. Enrichment of GO terms in 367 significantly down-regulated genes (gene list) was calculated relative to the total of 4075 genes detected as expressed in this stage (background list). The GO terms listed are those considered significant from DAVID analysis (FDR < 5 %) and non-redundant by REVIGO filtering