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Table 2 Gene Ontology analysis of genes down-regulated in response to DHA in P. falciparum K1 trophozoites from RNA-seq analysis

From: Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

Term Count List Total Pop Hits Pop Total PValue FDR
GO:0005829 ~ cytosol 70 276 85 963 3.4E–26 4.2E–23
GO:0044445 ~ cytosolic part 54 276 62 963 4.6E–22 5.8E–19
GO:0006412 ~ translation 99 348 181 1139 3.1E–13 4.5E–10
GO:0005840 ~ ribosome 68 276 117 963 3.1E–12 3.8E–09
GO:0003735 ~ structural constituent of ribosome 62 407 101 1385 1.4E–11 2.0E–08
GO:0022627 ~ cytosolic small ribosomal subunit 22 276 22 963 3.5E–11 4.3E–08
GO:0030529 ~ ribonucleoprotein complex 82 276 159 963 4.5E–11 5.6E–08
GO:0043228 ~ non-membrane-bounded organelle 87 276 186 963 7.1E–09 8.9E–06
GO:0005198 ~ structural molecule activity 65 407 120 1385 6.6E–09 9.3E–06
GO:0015935 ~ small ribosomal subunit 25 276 35 963 6.5E–07 8.1E–04
GO:0000502 ~ proteasome complex 20 276 30 963 5.9E–05 7.4E–02
GO:0044265 ~ cellular macromolecule catabolic process 29 348 55 1139 9.2E–04 1.3E + 00
  1. Enrichment of GO terms in 1137 significantly down-regulated genes (gene list) was calculated relative to the total of 4636 genes detected as expressed in this stage (background list). The GO terms listed are those considered significant from DAVID analysis (FDR < 5 %) and non-redundant by REVIGO filtering