Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

Table 2 Gene Ontology analysis of genes down-regulated in response to DHA in P. falciparum K1 trophozoites from RNA-seq analysis

Term	Count	List Total	Pop Hits	Pop Total	PValue	FDR
GO:0005829 ~ cytosol	70	276	85	963	3.4E–26	4.2E–23
GO:0044445 ~ cytosolic part	54	276	62	963	4.6E–22	5.8E–19
GO:0006412 ~ translation	99	348	181	1139	3.1E–13	4.5E–10
GO:0005840 ~ ribosome	68	276	117	963	3.1E–12	3.8E–09
GO:0003735 ~ structural constituent of ribosome	62	407	101	1385	1.4E–11	2.0E–08
GO:0022627 ~ cytosolic small ribosomal subunit	22	276	22	963	3.5E–11	4.3E–08
GO:0030529 ~ ribonucleoprotein complex	82	276	159	963	4.5E–11	5.6E–08
GO:0043228 ~ non-membrane-bounded organelle	87	276	186	963	7.1E–09	8.9E–06
GO:0005198 ~ structural molecule activity	65	407	120	1385	6.6E–09	9.3E–06
GO:0015935 ~ small ribosomal subunit	25	276	35	963	6.5E–07	8.1E–04
GO:0000502 ~ proteasome complex	20	276	30	963	5.9E–05	7.4E–02
GO:0044265 ~ cellular macromolecule catabolic process	29	348	55	1139	9.2E–04	1.3E + 00

Enrichment of GO terms in 1137 significantly down-regulated genes (gene list) was calculated relative to the total of 4636 genes detected as expressed in this stage (background list). The GO terms listed are those considered significant from DAVID analysis (FDR < 5 %) and non-redundant by REVIGO filtering

ISSN: 1471-2164