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Fig. 4 | BMC Genomics

Fig. 4

From: Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions

Fig. 4

Effects of CsA on the expression of genes involved in endoplasmic reticulum stress and FXR-regulated pathways in WT-PCLS and FXRKO-PCLS. Pathway analysis was performed in MetaCore using as input significant genes (FDR ≤ 0.05) regulated by CsA in WT-PCLS and FXRKO-PCLS. Pathways were considered as significant if FDR ≤0.005. Among the most significantly regulated pathways were “Endoplasmic reticulum (ER) stress response pathway” (a) and “Bile acids regulation of glucose and lipid metabolism via FXR “(b). Blue and red bars indicate down-and up-regulation respectively of significantly affected genes. Numbers 1 and 2 below the bars indicate WT-PCLS and FXRKO-PCLS, respectively. Each bar represents average fold change of gene expression (treatment vs. control) in liver slices from five mice. For an explanation of the other MetaCore symbols is referred to http://pathwaymaps.com/pdf/MC_legend.pdf

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BMC Genomics

ISSN: 1471-2164

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