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Fig. 7 | BMC Genomics

Fig. 7

From: Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions

Fig. 7

Functional and hierarchical clustering analysis of genes identified in GO processes related to “mitochondrion” uniquely regulated in FXRKO-PCLS. Genes identified in the significant GO-processes (FDR ≤ 0.005) related to “mitochondrion” in FXRKO-PCLS are presented as a network and a heat map. The network consists of 9 functional clusters shown as circles and denoted as: protein/amino acid (aa) processing n (1), NADH dehydrogenases (2), mitochondrial transporters (3), β-oxidation (4), CoA metabolism (5), mitochondrial ribosomal proteins (6), glucose metabolism (7), mitochondrial homeostasis (8), and xenobiotics metabolism (9). The heat map is the result of hierarchical clustering of log2, median centered, gene expression values in slices obtained from individual mice. For explanation of the lines, spheres, the heat map, and abbreviations, see Fig. 5

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BMC Genomics

ISSN: 1471-2164

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