Table 1 Common candidate genes for DGRP and extreme QTL GWA analyses previously associated with alcohol-related phenotypes in humans
Drosophila gene symbol | Biological process | Human gene symbol |
|---|---|---|
CAP | Muscle attachment; sensory perception of sound | CAP2 [82] |
CG31690 | - | TMTC2 [63] |
Dys | Imaginal disc-derived wing vein morphogenesis; neuromuscular synaptic transmission; muscle organ development | |
fz | Wnt signaling pathway; signal transduction; axon extension; heart development; negative regulation of Notch signaling pathway; establishment or maintenance of cell polarity | FZD9 [82] |
IA-2 | Protein dephosphorylation; regulation of secretion | PTPRN2 [14] |
KCNQ | Potassium ion transport; embryonic development via the syncytial blastoderm; regulation of heart rate | |
luna | Regulation of transcription, DNA-templated; mitotic sister chromatid segregation | KLF7 [110] |
milt | Axon transport of mitochondrion | TRAK2 [63] |
mtt | Phospholipase C-activating G-protein coupled receptor signaling pathway; response to insecticide; adult feeding behavior | GRM5 [12] |
Nrx-IV | Dorsal closure; protein localization; synaptic vesicle targeting; cell-cell junction organization; establishment or maintenance of cell polarity | |
Pde1c | cGMP metabolic process; cAMP metabolic process | |
Rbp6 | Stem cell development | MSI2 [112] |
rhea | Cell adhesion; muscle attachment; regulation of cell shape; larval somatic muscle development; negative regulation of transcription, DNA-templated; phagocytosis | TLN2 [63] |
shn | Ectoderm development; cell proliferation; learning or memory; olfactory learning; transforming growth factor beta receptor signaling pathway; peripheral nervous system development; positive regulation of transcription from RNA polymerase II promoter | HIVEP1 [63] |
stan | Establishment of planar polarity; cell adhesion; axonogenesis; mushroom body development; Wnt signaling pathway; negative regulation of Notch signaling pathway | CELSR1 [113] |