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Table 1 Common candidate genes for DGRP and extreme QTL GWA analyses previously associated with alcohol-related phenotypes in humans

From: Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila

Drosophila gene symbol Biological process Human gene symbol
CAP Muscle attachment; sensory perception of sound CAP2 [82]
CG31690 - TMTC2 [63]
Dys Imaginal disc-derived wing vein morphogenesis; neuromuscular synaptic transmission; muscle organ development DMD, UTRN [14, 63]
fz Wnt signaling pathway; signal transduction; axon extension; heart development; negative regulation of Notch signaling pathway; establishment or maintenance of cell polarity FZD9 [82]
IA-2 Protein dephosphorylation; regulation of secretion PTPRN2 [14]
KCNQ Potassium ion transport; embryonic development via the syncytial blastoderm; regulation of heart rate KCNQ3 [63, 64]
luna Regulation of transcription, DNA-templated; mitotic sister chromatid segregation KLF7 [110]
milt Axon transport of mitochondrion TRAK2 [63]
mtt Phospholipase C-activating G-protein coupled receptor signaling pathway; response to insecticide; adult feeding behavior GRM5 [12]
Nrx-IV Dorsal closure; protein localization; synaptic vesicle targeting; cell-cell junction organization; establishment or maintenance of cell polarity CHRNA5, CHRNA 7 [10, 83, 111]
Pde1c cGMP metabolic process; cAMP metabolic process PDE1C [63, 64]
Rbp6 Stem cell development MSI2 [112]
rhea Cell adhesion; muscle attachment; regulation of cell shape; larval somatic muscle development; negative regulation of transcription, DNA-templated; phagocytosis TLN2 [63]
shn Ectoderm development; cell proliferation; learning or memory; olfactory learning; transforming growth factor beta receptor signaling pathway; peripheral nervous system development; positive regulation of transcription from RNA polymerase II promoter HIVEP1 [63]
stan Establishment of planar polarity; cell adhesion; axonogenesis; mushroom body development; Wnt signaling pathway; negative regulation of Notch signaling pathway CELSR1 [113]