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Table 1 I PA categories, genes and p-values for Cannonical Pathways

From: Patterns of gene expression and DNA methylation in human fetal and adult liver

Pathway Genes P-value
Nicotine Degradation II FMO3,CYP1A1,UGT2B7,CYP2C18,CYP2C9,INMT,CYP1B1,UGT2B15, CYP1A2,CYP2D6,CYP2E1,CYP2A6,CYP2B6,AOX1,CYP2C8 5.62 × 10−18
Nicotine Degradation III CYP1A1,UGT2B7,CYP2C18,CYP2C9,CYP1B1,UGT2B15,CYP1A2,CYP2E1, CYP2D6,CYP2A6,AOX1,CYP2B6,CYP2C8 1.54 × 10−15
Bupropion Degradation CYP1A1,CYP1A2,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6,CYP2B6, CYP1B1,CYP2C8 5.92 × 10−14
Acetone Degradation I (to Methylglyoxal) CYP1A1,CYP1A2,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6,CYP2B6, CYP1B1,CYP2C8 5.92 × 10−14
Melatonin Degradation I CYP1A1,CYP1A2,UGT2B7,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6, CYP2B6,CYP1B1,CYP2C8,UGT2B15 6.05 × 10−14
Estrogen Biosynthesis CYP1A1,CYP1A2,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6,CYP2B6, AKR1C4,CYP1B1,CYP2C8 8.47 × 10−14
Superpathway of Melatonin Degradation CYP1A1,CYP1A2,UGT2B7,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6, CYP2B6,CYP1B1,CYP2C8,UGT2B15 1.61 × 10−13
PXR/RXR Activation CYP1A2,CES3,CYP2C9,CYP2A6,CYP2B6,SULT2A1,CYP2C8 7.87 × 10−6
LPS/IL-1 Mediated Inhibition of RXR Function FMO3,SLC27A5,SLC10A1,ACSL4,CYP2C9,CYP2A6,CYP2B6,ABCC4, SULT2A1,CYP2C8 3.92 × 10−5