Table 1 I PA categories, genes and p-values for Cannonical Pathways
From: Patterns of gene expression and DNA methylation in human fetal and adult liver
Pathway | Genes | P-value |
|---|---|---|
Nicotine Degradation II | FMO3,CYP1A1,UGT2B7,CYP2C18,CYP2C9,INMT,CYP1B1,UGT2B15, CYP1A2,CYP2D6,CYP2E1,CYP2A6,CYP2B6,AOX1,CYP2C8 | 5.62 × 10−18 |
Nicotine Degradation III | CYP1A1,UGT2B7,CYP2C18,CYP2C9,CYP1B1,UGT2B15,CYP1A2,CYP2E1, CYP2D6,CYP2A6,AOX1,CYP2B6,CYP2C8 | 1.54 × 10−15 |
Bupropion Degradation | CYP1A1,CYP1A2,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6,CYP2B6, CYP1B1,CYP2C8 | 5.92 × 10−14 |
Acetone Degradation I (to Methylglyoxal) | CYP1A1,CYP1A2,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6,CYP2B6, CYP1B1,CYP2C8 | 5.92 × 10−14 |
Melatonin Degradation I | CYP1A1,CYP1A2,UGT2B7,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6, CYP2B6,CYP1B1,CYP2C8,UGT2B15 | 6.05 × 10−14 |
Estrogen Biosynthesis | CYP1A1,CYP1A2,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6,CYP2B6, AKR1C4,CYP1B1,CYP2C8 | 8.47 × 10−14 |
Superpathway of Melatonin Degradation | CYP1A1,CYP1A2,UGT2B7,CYP2E1,CYP2D6,CYP2C18,CYP2C9,CYP2A6, CYP2B6,CYP1B1,CYP2C8,UGT2B15 | 1.61 × 10−13 |
PXR/RXR Activation | CYP1A2,CES3,CYP2C9,CYP2A6,CYP2B6,SULT2A1,CYP2C8 | 7.87 × 10−6 |
LPS/IL-1 Mediated Inhibition of RXR Function | FMO3,SLC27A5,SLC10A1,ACSL4,CYP2C9,CYP2A6,CYP2B6,ABCC4, SULT2A1,CYP2C8 | 3.92 × 10−5 |