Fig. 3

Heterogeneous positions identified across the whole population genomes relative to M. tuberculosis H37Rv reference genome. aThe rifampicin mono-resistant isolate (R721) for patient 1 shows numerous heterogeneous variants relative to M. tuberculosis H37Rv while the follow-up MDR isolate (R807) has none. (b) For patient 2 the rifampicin mono-resist isolate (R912) showed no heterogeneous variants relative to M. tuberculosis H37Rv, while the follow-up MDR isolate (R1210) had numerous heterogeneous variants. R912 shared 2 variants (Rv0667 and Rv0672) with R1210, where the variant was present at 100 % in R912 but was a heterogeneous variant in R1210