Fig. 7

The midnight blue PAG module represents a highly connected module of genes involved in synaptic functions. a Gene Ontology of the midnight blue PAG module. Highly significant enrichment of gene ontology categories were observed in the midnight blue PAG module including GO terms related to cognition, nervous system development, synaptic function, glutamatergic synaptic transmission and cell adhesion. Categories linked to synapse function are shaded red and categories linked to cell adhesion are shaded blue. The level of significance for each category determines the intensity of shading, as per inset key. b Connectivity map of all genes involved in synaptic transmission within the midnight blue module. The topological overlap (TO) is indicated by the thickness and colour of the lines, with red lines representing the closest overlap/strongest connectivity. Nodes represent the connectivity value ‘Kw’ which represents the overall connectivity within the module for that gene. Larger nodes indicate higher connectivity. ARC (an immediate early gene that acts at the synapse) and glutamatergic synaptic receptors (such as GRM1/4, NLGN2 and GRIN2A/3A) represent hubs for these synaptic networks