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Table 1 A large proportion of differential footprints occurs in shared DHSs

From: Wellington-bootstrap: differential DNase-seq footprinting identifies cell-type determining transcription factors

Cell type A

Cell type B

DHSs in A

DHSs in B

DHSs shared between A and B

Sites over-footprinted in A

Sites in common DHSs over-footprinted in A

Sites over-footprinted in B

Sites in common DHSs over-footprinted in B

CD4

CD8

84,830

60,890

49,365

14,772

10,600 (71.8)

3874

3584 (92.5)

CD4

CD14

84,830

109,647

47,887

14,819

6219 (42)

17,932

7663 (42.7)

CD4

CD19

84,830

89,660

43,282

18,525

10,423 (56.3)

19,439

13,018 (67)

CD4

CD56

84,830

69,966

54,739

17,745

14,611 (82.3)

2616

2526 (96.6)

CD4

Spinal cord

84,830

197,751

34,812

24,652

9158 (37.1)

93,152

10,233 (11)

CD4

Fibroblasts

84,830

193,546

40,240

21,473

7087 (33)

118,265

11,741 (9.9)

CD8

CD14

60,890

109,647

32,185

11,602

6529 (56.3)

55,650

12,546 (22.5)

CD8

CD19

60,890

89,660

32,350

8780

5520 (62.9)

28,708

15,549 (54.2)

CD8

CD56

60,890

69,966

51,965

1458

1428 (97.9)

335

330 (98.5)

CD8

Spinal cord

60,890

197,751

27,631

13,128

5444 (41.5)

110,950

11,330 (10.2)

CD8

Fibroblasts

60,890

193,546

30,237

13,734

5894 (42.9)

156,418

15,573 (10)

CD14

CD19

109,647

89,660

36,349

48,031

15,909 (33.1)

27,111

18,140 (66.9)

CD14

CD56

109,647

69,966

33,900

54,850

17,845 (32.5)

7842

5357 (68.3)

CD14

Spinal cord

109,647

197,751

33,141

53,731

13,584 (25.3)

96,856

13,563 (14)

CD14

Fibroblasts

109,647

193,546

45,179

37,641

8383 (22.3)

108,482

12,677 (11.7)

CD19

CD56

89,660

69,966

35,766

31,561

19,315 (61.2)

5553

4130 (74.4)

CD19

Spinal cord

89,660

197,751

31,858

28,993

13,118 (45.2)

97,388

14,826 (15.2)

CD19

Fibroblasts

89,660

193,546

30,831

32,531

13,760 (42.3)

138,301

20,224 (14.6)

CD56

Spinal cord

69,966

197,751

28,731

8633

4404 (51)

110,996

13,892 (12.5)

CD56

Fibroblasts

69,966

193,546

31,469

9237

4769 (51.6)

154,923

20,024 (12.9)

Spinal cord

Fibroblasts

197,751

193,546

64,733

24,756

5497 (22.2)

35,202

9461 (26.9)

  1. Number of DHSs and shared DHSs, number of over-footprinted sites, and number of over-footprinted sites located in the overlap of shared DHSs are shown for pairs of cell types. For closely related cell types most differential footprints tend to be found in common DHSs (e.g. CD4+ vs. CD56+). Developmentally distant cell types, however, often have a large number of DHSs that are cell type specific, and therefore the majority of differential footprints are in cell-type specific DHSs (e.g. CD56+ cells vs. fibroblasts)