Table 7 A list of genes and their putative functions involved in ribosome biogenesis in P. falciparum
From: A bioinformatic survey of RNA-binding proteins in Plasmodium
Gene ID | Putative function | Named in P. falciparum | Remarks |
|---|---|---|---|
PF3D7_0218400 | DDX47 (Rrp8p) | PfRrp8p | *18S rRNA processing, participates in cleavages at A2, and to a lesser extent, A0 and A1 sites |
PF3D7_0721300 | DDX31 (Dbp7p) | PfDbp7p | 27S pre-ribosomal rRNA processing (60S ribosomal subunit biogenesis) [123] |
PF3D7_1419100 | DDX55 (Spb4p) | PfSpb4p | *5.8S/25S pre-ribosomal rRNA processing (60S ribosomal subunit biogenesis) |
PF3D7_1418900 | DDX10 (Dbp4p) | PfDbp4p | 18S rRNA processing |
PF3D7_1307300 | DDX18 (Dbp6p) | PfDbp6p | *27S pre-rRNA processing (60S ribosomal subunit biogenesis) |
PF3D7_1332700 | DDX49 (Rrp3p) | PfRrp3p | *60S ribosomal subunit assembly-27S pre-rRNA processing |
PF3D7_0827000 | DBP10 (DBP10) or DDX54 isoform 1 | PfDbp10p | *5.8S/25S rRNA processing |
PF3D7_1251500 | DDx27 (Drs1p) | PfDrs1p | *27S- > 25S rRNA conversion (60S ribosomal subunit biogenesis) |
PF3D7_0422700 | EIF4A3 (Fal1p) | PfFal1p | *18S rRNA processing, participates in cleavage at A0, A1 and A2 sites |
PF3D7_1021500 | DDX52 (Rok1p) | PfRok1p | *18S rRNA processing, participates in cleavage at A1 and A2 sites |
PF3D7_0527900 | DDX41 (Mak5p) | PfMak5p | *60S ribosome subunit assembly |
PF3D7_1302700 | DHX37 (dhr1p) | PfDhr1p | *18S rRNA processing, participates in cleavage at A0, A1 and A2 sites |
PF3D7_1445900 | DDX17 isoform 1 (Dbp2p) | PfDbp2p | *60S ribosomal subunit biogenesis |
PF3D7_0602100 | SKIV2L2 or Mtr4p | PfMtr4p | *5.8S rRNA processing |
PF3D7_0630900 | Has1p | PfHas1p | Maturation of 40S and 60S ribosomal subunits |
PF3D7_0504400 | DDX21 | PfDdx21p | RNA processing and nucleolar localization |
PF3D7_1217200 | Mrd1p | PfMrd1p | Release of base-paired U3 snoRNA within the pre-ribosomal complex [124] |
PF3D7_0409800 | Rei1p | PfRei1p | It has functional redundancy with yeast proteins Reh1 in cytoplasmic 60S subunit maturation |
PF3D7_1464400 | Bud20p | PfBud20p | Helps in shuttling pre-ribosomal 60S complex to cytoplasm; U1-like Zn-finger-containing protein |
PF3D7_1474500 | Splicing factor 3a | PfSF3a | Splicing of rRNA genes |
PF3D7_1465900 | 40S ribosomal protein S3-1 | Pf40S s3-1p | Multifaceted functional roles; involves in translation, binding to DNA, and regulating transcription of specific set of genes |
PF3D7_0208200 | KRR1 | PfKrr1p | Synthesis of 18S rRNA (SSU) processome component |
PF3D7_1469300 | Pno1p or Dim2p | PfDim2p | Shuttling of Dim1 rRNA from cytoplasm to nucleolus |
PF3D7_1466700 | NIP7 homolog | PfNip7p | 60S ribosome subunit biogenesis protein NIP7 homolog isoform 1; nucleolar pre-rRNA processing |
PF3D7_1417500 | NAP57 | PfNap57p | Pseudouridine synthase NAP57 or H/ACA ribonucleoprotein complex subunit 4 (5e-178), H. sapiens |
PF3D7_0907600 | SUI1 family protein | PfeIF | Eukaryotic translation initiation factor SUI1 family protein isoform 1 (formerly named as ligetin) |
PF3D7_0529500 | MCTS1 | PfMcts1 | May be initiation factor homolog |
PF3D7_1450600 | SAM dependent methyltrasferase | PfSam | RNA methylation |
PF3D7_0418700 | RNA-binding protein NOB1 | PfNob1p | Biogenesis of 40S rRNA through cleavage of D-site in 20S rRNA |