Fig. 9

Differential peaks are associated with DSB regions. a The association of differential H3K4me3 peaks with the hottest DSB hotspots. The DMC1 tags associated with differential H3K4me3 peaks were extracted from published datasets [12, 86], and intensity values were calculated and presented as log(#tags) on the left plot. The right plot is the intensity of all DSB hotspots signal from the whole dataset [86]. The median signal of DSB peaks associated with differential H3K4me3 peaks was higher than the median signal of all DSBs hotspots, suggesting that differential trimethylation peaks in ATZ-treated mice are associated with the strongest hotspots. b The PAR region in ATZ-treated mice has a decreased number of H3K4me3 marks. The DSB map was downloaded from GEO from a previously published work [86]. Plots from controls are in red, plots from treated samples are in blue, and the CpG island is shown in yellow