Table 1 Summary of putative HI gene clusters (HIBGCs) identified in MAR4 strains. The PTases present in each HIBGC are indicated along with the annotation of key biosynthetic genes
Gene cluster | PTC(s) present | HIBGC content | Product |
|---|---|---|---|
nap | PTC10, PTC6 | Type III polyketide synthase, three haloperoxidases, mev pathway | napyradiomycin |
HIBGC1 | PTC9 | FabH-like protein, AvrD-like protein | Unknown |
HIBGC2 | PTC13 | haloperoxidase | Unknown |
HIBGC3 | PTC2, PTC8, PTC11 | squalene-hopene cyclase | Unknown |
HIBGC4 | PTC2, PTC12 | squalene-hopene cyclase | Unknown |
HIBGC5 | PTC8, PTC11 | Found on very short contig, additional genes in this cluster may exist | Unknown |
HIBGC6 | PTC4 | isopentenyl pyrophosphate synthase | Unknown |
HIBGC7 | PTC3 | polyprenyl synthase | Unknown |
HIBGC8 | PTC7 | three haloperoxidases; found on very short contig, additional genes in this cluster may exist | Unknown |
HIBGC9 | PTC7, PTC5 | Two type III polyketide synthases; portion of this HIBGC is identical to HIBGC8 | marinonea |
HIBGC10 | N/A | indole PTase, phytoene synthase | Unknown |
HIBGC11 | PTC1 | full suite of phenazine biosynthesis genes (phzABCDEFG) | lavanducyanina |
HIBGC12 | PTC2 | squalene-hopene cyclase | Unknown |