Fig. 1

ChIP-seq profile of FUS and EWS binding sites in the human genome. a Total number of ChIP-seq reads and the ChIP-seq reads mapped to the human genome for NGS sequenced samples. b Distribution in a gene based model of FUS, EWS, and Ac-H3K9 peaks in or nearby (within distance of 10 kb) genes. Upstream region (Up, red) is defined as until 10 kb upstream of annotated gene transcriptional start sites, downstream region (Down, blue) is defined as until 10 kb downstream of annotated gene poly(A)-signals, upstream + downstream (Up + Down, black) specifies a chromosomal localization in where a peak is until 10 kb upstream for one gene but at the same time downstream of a neighboring gene, exon (orange), intron (yellow), and exon and intron (exon is intron of another gene, green). The location is defined accordingly to the summit of a given peak. c Position binding profile of FUS, EWS, and Ac-H3K9 based on a transcript based model in where each annotated transcript with a FUS, EWS, or Ac-H3K9 peak, the peak is localized accordingly to the gene model illustrated in the upper left corner including the features upstream (1–100), exon/intron (100–200), and downstream (200–300), and each feature further subdivided in smaller segments. The y-axis represents the number of times (hits) each ChIP-seq peaks map to annotated UCSC gene transcripts at the given segment position in the feature. Since multiple annotated transcripts often appear from one gene due to alternative splicing and promoter usage each ChIP-seq peak can generate several hits. The location is defined accordingly to the summit of the given ChIP-seq peaks