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Fig. 2 | BMC Genomics

Fig. 2

From: Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2

Fig. 2

4E2 and 1p36 orthologous regions, and engineered mouse models used. a Human 1p36-p31.3 and mouse 4C5-E2 bands are orthologous (dashed lines). 1p36 and 4E2 are shown in dashed rectangles in their respective orthologous chromosome segments (grey rectangles). The 4.3 Mb deletion region inside mouse E2 is the focus of this study (top grey rectangle). b First generation (F1) Df/Dp male chimeras engineered in 129S5/SvEvBrd ES cells were mated with WT C57BL/6 J females to obtain heterozygote F1 Df/+  Bl6 D progeny. c Df/+  Bl6 D and +129/+Bl6 genotypes with corresponding chromosome name conventions used in this study. Df corresponds to the engineered 129S5/SvEvBrd chromosome 4 harboring the deletion in Df/+  Bl6 D MEFs, while +  Bl6 D corresponds to the WT C57BL/6 J chromosome 4. In + 129 /+ Bl6 MEFs, +129 corresponds to the 129S5/SvEvBrd WT chromosome 4 and +Bl6 corresponds to the WT C57BL/6 J chromosome 4. d The PE-4Cseq viewpoint positions along chromosome 4 selected for this study are indicated by arrows. Two viewpoints span ~2.5 Mb upstream of the deletion start, eight are located inside the deletion, and two cover ~1 Mb downstream of the deletion end

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