Fig. 3

Functional COG-categories of differentially regulated C. burnetii genes under in vivo and in vitro culture models. Functional categories of regulated genes of the 602 strain under in vivo and cell-free culture compared with cell culture model. The up-regulated and down-regulated genes are shown on the right and left side of the y-axis respectively. Largest group of regulated genes in all culture models belonged to the unknown function category (S). Large number of up-regulated genes under in vivo conditions belonged to the metabolism group such as coenzyme, carbohydrate, amino acid and lipid transport and metabolism (HGEI). Whereas, the largest number of up-regulated genes in cell-free culture compared to cell culture belonged to the protein synthesis group (O)