Fig. 2

Phylogeny of the trehalose and glucose transporter family. The figure shows a phylogenetic tree of trehalose and glucose transporters from vertebrates, trematodes and insects. The topologies obtained with ML, MP and NJ methods were similar, and thus only ML is displayed. Numbers on internal branches are the bootstrap values (only >80 % are shown); the statistical support obtained with approximate likelihood ratio test (aLRT) was similar. Sequences are labeled with data collected from GenBank as name of species (four first letters), type of transporters (T: trehalose, G: glucose), number (if reported) of the sugar transporter and accession numbers. S. mansoni glucose transporters are indicated by asterisks. Homo sapiens GLUT1 and GLUT4 are highlighted in red. The classes of glucose transporters are numbered with roman numerals. D. melanogaster sucrose transporter was used as the outgroup. The labels for the species used are as follow: Mammals: H. sapiens (Hsap), Mus musculus (Mmus), Bos Taurus (Btau); Fish: Oreochromis niloticus (Onil), Neolamprologus brichardi (Nbri), Haplochromis burtoni (Hbur), Pundamilia nyererei (Pnye), Larimichthys crocea (Lcro), Dicentrarchus labrax (Dlab), Maylandia zebra (Mzeb); Insects: Anopheles gambiae (Agam), Aedes aegypti (Aaeg), Apis mellifera (Amel), Bombyx mori (Bmor), Drosophila melanogaster (Dmel), Drosophila pseudoobscura pseudoobscura (Dpse), Gastric caeca (Gcae), Solenopsis Invicta (Sinv); Cestodes: Taenia solium (Tsol), Echinococcus granulosus (Egra), Echinococcus multilocularis (Emul), Hymenolepis microstoma (Hmic), Fasciola gigantica (Fgig), Fasciola hepatica (Fhep); Flukes: Clonorchis sinensis (Csin), S. haematobium (Shae), Opisthorchis viverrini (Oviv), S. japonicum (Sjap)